STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egl-23Uncharacterized protein; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (726 aa)    
Predicted Functional Partners:
kcnl-4
CaMBD domain-containing protein.
   
  
 0.762
K08D8.4
CUB domain-containing protein.
   
  
 0.702
sup-9
Two pore potassium channel protein sup-9; Potassium channel involved in coordination of muscle contraction. Activity is regulated by sup-18 ; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
0.691
sup-18
Iodotyrosine dehalogenase 1 homolog; May contribute to coordination of muscle contraction as regulatory subunit of the nonessential sup-9 potassium channel complex. May act downstream of sup-10.
   
  
 0.670
tag-68
Dwarfin sma.
   
  
 0.667
irk-2
Inward Rectifying K (Potassium) channel family.
   
  
 0.666
R12E2.15
Uncharacterized protein.
      
 0.660
twk-14
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
 
0.656
twk-46
Two pore potassium channel protein sup-9.
     
0.647
ccb-2
SH3 domain-containing protein.
      
 0.620
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.