node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C34F6.9 | siah-1 | C34F6.9.1 | Y37E11AR.2.1 | USP domain-containing protein; Belongs to the peptidase C19 family. | E3 ubiquitin-protein ligase siah-1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. | 0.701 |
C34F6.9 | usp-5 | C34F6.9.1 | T27A3.2.1 | USP domain-containing protein; Belongs to the peptidase C19 family. | Ubiquitin carboxyl-terminal hydrolase. | 0.590 |
bar-1 | gpd-1 | C54D1.6.1 | T09F3.3.2 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] | Glyceraldehyde-3-phosphate dehydrogenase 1. | 0.459 |
bar-1 | gpd-3 | C54D1.6.1 | K10B3.7.2 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] | Glyceraldehyde-3-phosphate dehydrogenase 3. | 0.473 |
bar-1 | gpd-4 | C54D1.6.1 | F33H1.2.2 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] | Glyceraldehyde-3-phosphate dehydrogenase 4. | 0.459 |
bar-1 | hmp-2 | C54D1.6.1 | K05C4.6b.1 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] | Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions. | 0.956 |
bar-1 | siah-1 | C54D1.6.1 | Y37E11AR.2.1 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] | E3 ubiquitin-protein ligase siah-1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. | 0.932 |
bar-1 | wrm-1 | C54D1.6.1 | B0336.1a.1 | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] | Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] | 0.951 |
gpd-1 | bar-1 | T09F3.3.2 | C54D1.6.1 | Glyceraldehyde-3-phosphate dehydrogenase 1. | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] | 0.459 |
gpd-1 | gpd-3 | T09F3.3.2 | K10B3.7.2 | Glyceraldehyde-3-phosphate dehydrogenase 1. | Glyceraldehyde-3-phosphate dehydrogenase 3. | 0.618 |
gpd-1 | gpd-4 | T09F3.3.2 | F33H1.2.2 | Glyceraldehyde-3-phosphate dehydrogenase 1. | Glyceraldehyde-3-phosphate dehydrogenase 4. | 0.824 |
gpd-1 | hmp-2 | T09F3.3.2 | K05C4.6b.1 | Glyceraldehyde-3-phosphate dehydrogenase 1. | Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions. | 0.490 |
gpd-1 | siah-1 | T09F3.3.2 | Y37E11AR.2.1 | Glyceraldehyde-3-phosphate dehydrogenase 1. | E3 ubiquitin-protein ligase siah-1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. | 0.708 |
gpd-1 | wrm-1 | T09F3.3.2 | B0336.1a.1 | Glyceraldehyde-3-phosphate dehydrogenase 1. | Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] | 0.488 |
gpd-3 | bar-1 | K10B3.7.2 | C54D1.6.1 | Glyceraldehyde-3-phosphate dehydrogenase 3. | Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...] | 0.473 |
gpd-3 | gpd-1 | K10B3.7.2 | T09F3.3.2 | Glyceraldehyde-3-phosphate dehydrogenase 3. | Glyceraldehyde-3-phosphate dehydrogenase 1. | 0.618 |
gpd-3 | gpd-4 | K10B3.7.2 | F33H1.2.2 | Glyceraldehyde-3-phosphate dehydrogenase 3. | Glyceraldehyde-3-phosphate dehydrogenase 4. | 0.618 |
gpd-3 | hmp-2 | K10B3.7.2 | K05C4.6b.1 | Glyceraldehyde-3-phosphate dehydrogenase 3. | Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions. | 0.460 |
gpd-3 | siah-1 | K10B3.7.2 | Y37E11AR.2.1 | Glyceraldehyde-3-phosphate dehydrogenase 3. | E3 ubiquitin-protein ligase siah-1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates. | 0.672 |
gpd-3 | wrm-1 | K10B3.7.2 | B0336.1a.1 | Glyceraldehyde-3-phosphate dehydrogenase 3. | Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...] | 0.459 |