node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ced-10 | efn-2 | C09G12.8b.1 | C43F9.8.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.588 |
ced-10 | efn-3 | C09G12.8b.1 | F15A2.5.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.513 |
ced-10 | efn-4 | C09G12.8b.1 | F56A11.3.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. | 0.568 |
ced-10 | gei-1 | C09G12.8b.1 | F45H7.2a.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | START domain-containing protein. | 0.544 |
ced-10 | nck-1 | C09G12.8b.1 | ZK470.5a.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. | 0.692 |
ced-10 | sax-3 | C09G12.8b.1 | ZK377.2b.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | Protein sax-3; Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Belongs to the immunoglobulin superfamily. ROBO/SAX3 family. | 0.718 |
ced-10 | slt-1 | C09G12.8b.1 | F40E10.4.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. | 0.715 |
ced-10 | vab-1 | C09G12.8b.1 | M03A1.1b.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] | 0.734 |
ced-10 | vab-2 | C09G12.8b.1 | Y37E11AR.6a.1 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.602 |
efn-2 | ced-10 | C43F9.8.1 | C09G12.8b.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | 0.588 |
efn-2 | efn-3 | C43F9.8.1 | F15A2.5.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.564 |
efn-2 | efn-4 | C43F9.8.1 | F56A11.3.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. | 0.607 |
efn-2 | nck-1 | C43F9.8.1 | ZK470.5a.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. | 0.701 |
efn-2 | sax-3 | C43F9.8.1 | ZK377.2b.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Protein sax-3; Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Belongs to the immunoglobulin superfamily. ROBO/SAX3 family. | 0.528 |
efn-2 | slt-1 | C43F9.8.1 | F40E10.4.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development. | 0.477 |
efn-2 | vab-1 | C43F9.8.1 | M03A1.1b.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] | 0.979 |
efn-2 | vab-2 | C43F9.8.1 | Y37E11AR.6a.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.595 |
efn-3 | ced-10 | F15A2.5.1 | C09G12.8b.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] | 0.513 |
efn-3 | efn-2 | F15A2.5.1 | C43F9.8.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.564 |
efn-3 | efn-4 | F15A2.5.1 | F56A11.3.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. | 0.614 |