STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
unc-33Protein unc-33; During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons. Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins. This is achieved in part by regulating the localization of kinesin-like protein unc-104. In neurons without a distal microtubule- organizing center (MTOC), also controls the organization of microtubules in dendrites. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Ra [...] (854 aa)    
Predicted Functional Partners:
pyr-1
Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (By similarity). Involved in the elongation of the pharyngeal isthmus during development, probably by providing precursors of UDP- sugars required for heparan sulfate proteoglycan biosynthesis. Regulates the organization of the actin and intermediate filaments cytoskeleton in the pharyngeal muscles ; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
  
 0.972
eas-1
Probable Golgi transport protein 1; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family.
  
 
 0.914
unc-44
Uncharacterized protein.
   
 
 0.892
dpyd-1
Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). Involved in the degradation of the chemotherapeutic drug 5-fluorouracil.
  
 0.888
dhod-1
Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.883
T09F3.2
Carrier protein (C2); Belongs to the mitochondrial carrier (TC 2.A.29) family.
  
 
 0.874
F38B6.4
Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.
  
  
 0.845
Y62E10A.6
NADPH:adrenodoxin oxidoreductase, mitochondrial.
  
 
 0.800
Y52B11A.3
Uncharacterized protein.
  
 
 0.793
T05H4.4
NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
  
 
 0.786
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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