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ced-2 protein (Caenorhabditis elegans) - STRING interaction network
"ced-2" - Cell death abnormality protein 2 in Caenorhabditis elegans
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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ced-2Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs) (279 aa)    
Predicted Functional Partners:
ced-5
CED-5; Protein CED-5 (ced-5) mRNA, complete cds; Belongs to the DOCK family (1781 aa)
     
  0.999
ced-12
Cell death abnormality protein 12; Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Negatively regulates the unc- 6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body. Plays no role in amphid axon outgrowth (731 aa)
     
  0.999
abl-1
Tyrosine-protein kinase abl-1; Functions downstream of migratory protein mig-13 and is involved in Q neuroblast migration during larval development. Recruited by mig-13 to the leading edge of Q neuroblasts and their descendents to signal downstream, likely to the wve-1 pathway, and direct migration along the anteroposterior body axis. Promotes germline cell apoptosis in response to oxidative, osmotic and heat shock stresses; Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily (1224 aa)
     
  0.997
Y34B4A.4
Protein Y34B4A.4, isoform a (Y34B4A.4) mRNA, complete cds (877 aa)
     
  0.995
sli-1
Suppressor of LIneage defect; Protein SLI-1, isoform b (sli-1) mRNA, complete cds (582 aa)
       
  0.987
ced-10
Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
     
 
  0.986
pxl-1
Paxillin homolog 1; Protein PXL-1, isoform a (413 aa)
     
  0.986
psr-1
Bifunctional arginine demethylase and lysyl-hydroxylase psr-1; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase (416 aa)
     
 
  0.947
sem-5
Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl-15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the l [...] (228 aa)
     
0.941
F46H5.4
Protein F46H5.4 (F46H5.4) mRNA, complete cds; Belongs to the DOCK family (2018 aa)
     
  0.939
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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