node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hyls-1 | sas-4 | C05C8.9a.1 | F10E9.8.1 | Hydrolethalus syndrome protein 1 homolog; Plays an important role ciliogenesis. Belongs to the HYLS1 family. | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | 0.923 |
hyls-1 | sas-5 | C05C8.9a.1 | F35B12.5a.2 | Hydrolethalus syndrome protein 1 homolog; Plays an important role ciliogenesis. Belongs to the HYLS1 family. | Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. | 0.601 |
hyls-1 | sas-6 | C05C8.9a.1 | Y45F10D.9.1 | Hydrolethalus syndrome protein 1 homolog; Plays an important role ciliogenesis. Belongs to the HYLS1 family. | Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. | 0.723 |
hyls-1 | spd-2 | C05C8.9a.1 | F32H2.3.1 | Hydrolethalus syndrome protein 1 homolog; Plays an important role ciliogenesis. Belongs to the HYLS1 family. | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. | 0.493 |
lin-2 | sas-6 | F17E5.1a.1 | Y45F10D.9.1 | Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions. | Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. | 0.677 |
sas-4 | hyls-1 | F10E9.8.1 | C05C8.9a.1 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Hydrolethalus syndrome protein 1 homolog; Plays an important role ciliogenesis. Belongs to the HYLS1 family. | 0.923 |
sas-4 | sas-5 | F10E9.8.1 | F35B12.5a.2 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. | 0.991 |
sas-4 | sas-6 | F10E9.8.1 | Y45F10D.9.1 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. | 0.979 |
sas-4 | sas-7 | F10E9.8.1 | T07C4.10.1 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Uncharacterized protein. | 0.940 |
sas-4 | spd-2 | F10E9.8.1 | F32H2.3.1 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. | 0.951 |
sas-4 | spd-5 | F10E9.8.1 | F56A3.4.1 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. | 0.929 |
sas-4 | szy-20 | F10E9.8.1 | C18E9.3d.1 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Suppressor of zyg-1 protein 20; RNA binding protein that is required for normal cell division and cytokinesis during embryonic development. Functions with RNA-binding protein atx-2 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Furthermore, negatively regulates the levels of the protein kinase zyg-1 at the centrosome. Also involved in ensuring centrosome attachment to the nuclear envelope. | 0.846 |
sas-4 | tac-1 | F10E9.8.1 | Y54E2A.3.1 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Transforming acid coiled-coil-containing protein 1; Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is requ [...] | 0.721 |
sas-4 | zyg-1 | F10E9.8.1 | F59E12.2.2 | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | Probable serine/threonine-protein kinase zyg-1; Protein kinase that plays a central role in centrosome duplication, control of centrosome size, spindle formation and nuclear envelope breakdown during cell divisions. Paternal copy is required to regulate synthesis of daughter centrioles prior to fertilization. Maternal copy regulates centrosome duplication during later cell cycles. Functions upstream of sas-5 and sas-6, and is required for their localization to the centrosome. Its role in nuclear envelope breakdown is mediated by the spindly-like protein spdl-1 and the RZZ complex, whic [...] | 0.987 |
sas-5 | hyls-1 | F35B12.5a.2 | C05C8.9a.1 | Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. | Hydrolethalus syndrome protein 1 homolog; Plays an important role ciliogenesis. Belongs to the HYLS1 family. | 0.601 |
sas-5 | sas-4 | F35B12.5a.2 | F10E9.8.1 | Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. | Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. | 0.991 |
sas-5 | sas-6 | F35B12.5a.2 | Y45F10D.9.1 | Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. | Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication. | 0.997 |
sas-5 | sas-7 | F35B12.5a.2 | T07C4.10.1 | Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. | Uncharacterized protein. | 0.854 |
sas-5 | spd-2 | F35B12.5a.2 | F32H2.3.1 | Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. | 0.932 |
sas-5 | spd-5 | F35B12.5a.2 | F56A3.4.1 | Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis. | Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development. | 0.817 |