STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hsp-16.41Heat shock protein Hsp-16.41; Belongs to the small heat shock protein (HSP20) family. (143 aa)    
Predicted Functional Partners:
hsp-16.2
Heat shock protein Hsp-16.2; Belongs to the small heat shock protein (HSP20) family.
  
0.999
hsp-70
Heat Shock Protein; Belongs to the heat shock protein 70 family.
   
 
 0.871
hsp-16.49
Heat shock protein Hsp-16.48/Hsp-16.49.
  
  
0.865
hsp-12.6
SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.
  
  
 0.857
F44E5.4
Uncharacterized protein; Belongs to the heat shock protein 70 family.
   
 
 0.854
hsp-16.11
Heat shock protein Hsp-16.1/Hsp-16.11.
   
0.763
hsp-16.1
Heat shock protein Hsp-16.1/Hsp-16.11.
   
  
0.646
ilc-17.1
Interleukin cytokine-related protein 17.1; Ligand for the receptor complex composed of ilcr-1 and ilcr- 2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones; Belongs to the IL-17 family.
      
 0.637
hsf-1
HSF_DOMAIN domain-containing protein.
    
 0.635
hsp-16.48
Heat shock protein Hsp-16.48/Hsp-16.49; Belongs to the small heat shock protein (HSP20) family.
  
 
0.634
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.