node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F44E5.4 | daf-16 | F44E5.4.1 | R13H8.1h.1 | Uncharacterized protein; Belongs to the heat shock protein 70 family. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.403 |
F44E5.4 | hsf-1 | F44E5.4.1 | Y53C10A.12.1 | Uncharacterized protein; Belongs to the heat shock protein 70 family. | HSF_DOMAIN domain-containing protein. | 0.756 |
F44E5.4 | hsp-12.6 | F44E5.4.1 | F38E11.2.1 | Uncharacterized protein; Belongs to the heat shock protein 70 family. | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. | 0.515 |
F44E5.4 | hsp-16.1 | F44E5.4.1 | T27E4.8.1 | Uncharacterized protein; Belongs to the heat shock protein 70 family. | Heat shock protein Hsp-16.1/Hsp-16.11. | 0.956 |
F44E5.4 | hsp-16.2 | F44E5.4.1 | Y46H3A.3a.1 | Uncharacterized protein; Belongs to the heat shock protein 70 family. | Heat shock protein Hsp-16.2; Belongs to the small heat shock protein (HSP20) family. | 0.974 |
F44E5.4 | hsp-16.41 | F44E5.4.1 | Y46H3A.2.1 | Uncharacterized protein; Belongs to the heat shock protein 70 family. | Heat shock protein Hsp-16.41; Belongs to the small heat shock protein (HSP20) family. | 0.854 |
F44E5.4 | hsp-70 | F44E5.4.1 | C12C8.1.1 | Uncharacterized protein; Belongs to the heat shock protein 70 family. | Heat Shock Protein; Belongs to the heat shock protein 70 family. | 0.546 |
daf-16 | F44E5.4 | R13H8.1h.1 | F44E5.4.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Uncharacterized protein; Belongs to the heat shock protein 70 family. | 0.403 |
daf-16 | gst-4 | R13H8.1h.1 | K08F4.7.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. | 0.891 |
daf-16 | hsf-1 | R13H8.1h.1 | Y53C10A.12.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | HSF_DOMAIN domain-containing protein. | 0.927 |
daf-16 | hsp-12.6 | R13H8.1h.1 | F38E11.2.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. | 0.809 |
daf-16 | hsp-16.1 | R13H8.1h.1 | T27E4.8.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Heat shock protein Hsp-16.1/Hsp-16.11. | 0.761 |
daf-16 | hsp-16.2 | R13H8.1h.1 | Y46H3A.3a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Heat shock protein Hsp-16.2; Belongs to the small heat shock protein (HSP20) family. | 0.913 |
daf-16 | hsp-70 | R13H8.1h.1 | C12C8.1.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Heat Shock Protein; Belongs to the heat shock protein 70 family. | 0.863 |
daf-16 | skn-1 | R13H8.1h.1 | T19E7.2a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] | 0.976 |
daf-16 | sod-3 | R13H8.1h.1 | C08A9.1.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Superoxide dismutase [Mn] 2, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. | 0.935 |
gst-4 | daf-16 | K08F4.7.1 | R13H8.1h.1 | Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.891 |
gst-4 | hsf-1 | K08F4.7.1 | Y53C10A.12.1 | Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. | HSF_DOMAIN domain-containing protein. | 0.801 |
gst-4 | hsp-12.6 | K08F4.7.1 | F38E11.2.1 | Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. | 0.534 |
gst-4 | hsp-16.1 | K08F4.7.1 | T27E4.8.1 | Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. | Heat shock protein Hsp-16.1/Hsp-16.11. | 0.696 |