node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aak-1 | aak-2 | PAR2.3a.2 | T01C8.1b.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 0.910 |
aak-1 | aakb-2 | PAR2.3a.2 | Y47D3A.15.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | AMPKBI domain-containing protein. | 0.980 |
aak-1 | aakg-1 | PAR2.3a.2 | Y111B2A.8f.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | AMP-Activated protein Kinase Gamma subunit. | 0.989 |
aak-1 | aakg-2 | PAR2.3a.2 | T20F7.6.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | AMP-Activated protein Kinase Gamma subunit. | 0.666 |
aak-1 | aakg-3 | PAR2.3a.2 | Y41G9A.3.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | AMP-Activated protein Kinase Gamma subunit. | 0.666 |
aak-1 | aakg-4 | PAR2.3a.2 | T01B6.3a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | AMP-Activated protein Kinase Gamma subunit. | 0.666 |
aak-1 | aakg-5 | PAR2.3a.2 | R53.7b.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | AMP-Activated protein Kinase Gamma subunit. | 0.935 |
aak-1 | daf-16 | PAR2.3a.2 | R13H8.1h.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.971 |
aak-1 | let-363 | PAR2.3a.2 | B0261.2a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...] | 0.956 |
aak-1 | par-4 | PAR2.3a.2 | Y59A8B.14a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Controls the asymmetric cell division of the Q.p neuroblast lineage. Involved in mediating cell polarization via regulation of anillin family scaffold proteins. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. May phosphorylate par-1. Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein s [...] | 0.959 |
aak-2 | aak-1 | T01C8.1b.1 | PAR2.3a.2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. | 0.910 |
aak-2 | aakb-2 | T01C8.1b.1 | Y47D3A.15.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | AMPKBI domain-containing protein. | 0.997 |
aak-2 | aakg-1 | T01C8.1b.1 | Y111B2A.8f.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | AMP-Activated protein Kinase Gamma subunit. | 0.997 |
aak-2 | aakg-2 | T01C8.1b.1 | T20F7.6.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | AMP-Activated protein Kinase Gamma subunit. | 0.869 |
aak-2 | aakg-3 | T01C8.1b.1 | Y41G9A.3.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | AMP-Activated protein Kinase Gamma subunit. | 0.812 |
aak-2 | aakg-4 | T01C8.1b.1 | T01B6.3a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | AMP-Activated protein Kinase Gamma subunit. | 0.910 |
aak-2 | aakg-5 | T01C8.1b.1 | R53.7b.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | AMP-Activated protein Kinase Gamma subunit. | 0.983 |
aak-2 | daf-16 | T01C8.1b.1 | R13H8.1h.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.994 |
aak-2 | let-363 | T01C8.1b.1 | B0261.2a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...] | 0.984 |
aak-2 | par-4 | T01C8.1b.1 | Y59A8B.14a.1 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] | Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Controls the asymmetric cell division of the Q.p neuroblast lineage. Involved in mediating cell polarization via regulation of anillin family scaffold proteins. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. May phosphorylate par-1. Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein s [...] | 0.957 |