node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
his-40 | jhdm-1 | K03A1.1.1 | T26A5.5a.1 | Histone H3. | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. | 0.813 |
his-40 | jmjd-1.2 | K03A1.1.1 | F29B9.2c.1 | Histone H3. | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. | 0.953 |
his-40 | jmjd-2 | K03A1.1.1 | Y48B6A.11.1 | Histone H3. | Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion. | 0.817 |
his-40 | set-2 | K03A1.1.1 | C26E6.9c.1 | Histone H3. | Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] | 0.808 |
his-40 | set-30 | K03A1.1.1 | ZC8.3.1 | Histone H3. | MYND-type domain-containing protein. | 0.510 |
his-40 | utx-1 | K03A1.1.1 | D2021.1a.1 | Histone H3. | UTX (Ubiquitously transcribed TPR on X) homolog. | 0.924 |
jhdm-1 | his-40 | T26A5.5a.1 | K03A1.1.1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. | Histone H3. | 0.813 |
jhdm-1 | jmjd-2 | T26A5.5a.1 | Y48B6A.11.1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. | Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion. | 0.943 |
jhdm-1 | jmjd-5 | T26A5.5a.1 | C06H2.3a.1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. | Glucosamine 6-phosphate N-acetyltransferase. | 0.719 |
jhdm-1 | lsd-1 | T26A5.5a.1 | T08D10.2.1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. | 0.763 |
jhdm-1 | set-2 | T26A5.5a.1 | C26E6.9c.1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. | Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] | 0.787 |
jhdm-1 | spr-5 | T26A5.5a.1 | Y40B1B.6.1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] | 0.579 |
jhdm-1 | utx-1 | T26A5.5a.1 | D2021.1a.1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. | UTX (Ubiquitously transcribed TPR on X) homolog. | 0.868 |
jmjd-1.2 | his-40 | F29B9.2c.1 | K03A1.1.1 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. | Histone H3. | 0.953 |
jmjd-1.2 | jmjd-2 | F29B9.2c.1 | Y48B6A.11.1 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. | Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion. | 0.880 |
jmjd-1.2 | jmjd-5 | F29B9.2c.1 | C06H2.3a.1 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. | Glucosamine 6-phosphate N-acetyltransferase. | 0.749 |
jmjd-1.2 | set-2 | F29B9.2c.1 | C26E6.9c.1 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. | Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] | 0.522 |
jmjd-1.2 | set-26 | F29B9.2c.1 | Y51H4A.12.1 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. | Histone-lysine N-methyltransferase set-26; Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro. Involved in transcriptional regulation. Plays a role in the negative regulation of lifespan and in heat resistance. Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion. Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline. Together w [...] | 0.557 |
jmjd-1.2 | set-30 | F29B9.2c.1 | ZC8.3.1 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. | MYND-type domain-containing protein. | 0.401 |
jmjd-1.2 | spr-5 | F29B9.2c.1 | Y40B1B.6.1 | Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] | 0.492 |