STRINGSTRING
pie-1 protein (Caenorhabditis elegans) - STRING interaction network
"pie-1" - Pharynx and intestine in excess protein 1 in Caenorhabditis elegans
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pie-1Pharynx and intestine in excess protein 1; Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II- dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex (335 aa)    
Predicted Functional Partners:
oma-2
CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5’-UA[AU]- 3’ motifs in the 3’-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P- granule distribution during embryonic development (393 aa)
     
 
  0.999
mex-6
Zinc finger protein mex-6; Functions with mex-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells (467 aa)
     
 
  0.999
mex-5
Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells (468 aa)
     
 
  0.998
puf-5
Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5’-CUCUGUAUCUUGU-3’ in mRNA 3’-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis (553 aa)
     
 
  0.998
meg-1
Protein MEG-1 (meg-1) mRNA, complete cds (636 aa)
     
 
  0.997
oma-1
CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5’-UA[AU]- 3’ motifs in the 3’-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3’-UTR of mei-1 and zif [...] (407 aa)
     
 
  0.996
spn-4
PIP-1; Protein SPN-4 (spn-4) mRNA, complete cds (351 aa)
     
 
  0.992
W05F2.3
Protein W05F2.3 (W05F2.3) mRNA, complete cds (222 aa)
     
        0.990
pos-1
Cytoplasmic zinc-finger protein; Protein POS-1 (pos-1) mRNA, complete cds (264 aa)
     
 
0.987
C01G8.1
Protein C01G8.1, isoform b (C01G8.1) mRNA, complete cds (315 aa)
     
        0.987
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
Server load: low (21%) [HD]