node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
T27F6.6 | W02F12.2 | T27F6.6.1 | W02F12.2.1 | Putative neutral sphingomyelinase. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | 0.956 |
T27F6.6 | cgt-1 | T27F6.6.1 | T06C12.10.1 | Putative neutral sphingomyelinase. | Ceramide glucosyltransferase 1; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. | 0.927 |
T27F6.6 | cgt-2 | T27F6.6.1 | F20B4.6.1 | Putative neutral sphingomyelinase. | Ceramide glucosyltransferase 2; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. | 0.927 |
T27F6.6 | cgt-3 | T27F6.6.1 | F59G1.1b.1 | Putative neutral sphingomyelinase. | Ceramide glucosyltransferase 3; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Seems to be the major active form in the nematode. | 0.927 |
T27F6.6 | hyl-1 | T27F6.6.1 | C09G4.1b.1 | Putative neutral sphingomyelinase. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.934 |
T27F6.6 | hyl-2 | T27F6.6.1 | K02G10.6.1 | Putative neutral sphingomyelinase. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.962 |
T27F6.6 | lagr-1 | T27F6.6.1 | Y6B3B.10.1 | Putative neutral sphingomyelinase. | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. | 0.979 |
T27F6.6 | sphk-1 | T27F6.6.1 | C34C6.5a.1 | Putative neutral sphingomyelinase. | Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). | 0.545 |
T27F6.6 | ttm-5 | T27F6.6.1 | Y54E5A.1.1 | Putative neutral sphingomyelinase. | Putative sphingolipid delta(4)-desaturase/C4-monooxygenase; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. | 0.937 |
W02F12.2 | T27F6.6 | W02F12.2.1 | T27F6.6.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Putative neutral sphingomyelinase. | 0.956 |
W02F12.2 | cgt-1 | W02F12.2.1 | T06C12.10.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide glucosyltransferase 1; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. | 0.921 |
W02F12.2 | cgt-2 | W02F12.2.1 | F20B4.6.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide glucosyltransferase 2; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family. | 0.968 |
W02F12.2 | cgt-3 | W02F12.2.1 | F59G1.1b.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide glucosyltransferase 3; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Seems to be the major active form in the nematode. | 0.921 |
W02F12.2 | hyl-1 | W02F12.2.1 | C09G4.1b.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.942 |
W02F12.2 | hyl-2 | W02F12.2.1 | K02G10.6.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.955 |
W02F12.2 | lagr-1 | W02F12.2.1 | Y6B3B.10.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Probable ceramide synthase lagr-1; Catalyzes the acylation of sphingosine to form ceramides. | 0.944 |
W02F12.2 | sphk-1 | W02F12.2.1 | C34C6.5a.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses (Probable). | 0.959 |
W02F12.2 | ttm-5 | W02F12.2.1 | Y54E5A.1.1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family. | Putative sphingolipid delta(4)-desaturase/C4-monooxygenase; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. | 0.978 |
Y37E11AM.3 | hyl-1 | Y37E11AM.3b.1 | C09G4.1b.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. | 0.943 |
Y37E11AM.3 | hyl-2 | Y37E11AM.3b.1 | K02G10.6.1 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2. | 0.942 |