STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
faah-4Monoglyceride lipase faah-4; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2- arachidonoylglycerol (2-AG), and thereby regulates the degradation of endocannabinoid-related monoacylglycerides. Also hydrolyzes arachidonoyl ethanolamide (anandamide, or AEA), but with low efficiency. Plays a role in the regulation of longevity and resistance to oxidative stress. Belongs to the amidase family. (647 aa)    
Predicted Functional Partners:
C39B5.6
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.
 
 0.945
faah-1
Fatty acid amide hydrolase 1; Degrades bioactive fatty acid amides like palmitoyl ethanolamide (PEA), palmitoleoyl ethanolamide (POEA), oleoyl ethanolamide (OEA), linoleoyl ethanolamide (LOEA), arachidonoyl ethanolamide (anandamide, or AEA), and eicosapentaneoyl ethanolamide (EPEA), thereby serving to terminate the signaling functions of these molecules. EPEA promotes dauer formation and may constitute a signal of high nutrient availability. Breakdown of EPEA may promote lifespan extension when nutrient availability is high. Facilitates axon regeneration after injury by degradating inh [...]
  
  
0.929
faah-6
Amidase domain-containing protein.
  
  
0.913
abhd-12
Hydrolase_4 domain-containing protein.
   
  
 0.882
nape-2
Lactamase_B domain-containing protein.
     
 0.841
F15A8.6
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
      
 0.806
K11G9.2
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
      
 0.806
Y71H2AM.13
COesterase domain-containing protein.
      
 0.806
nape-1
Lactamase_B domain-containing protein.
     
 0.795
dars-2
AA_TRNA_LIGASE_II domain-containing protein.
  
 0.785
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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