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top-3 protein (Caenorhabditis elegans) - STRING interaction network
"top-3" - DNA topoisomerase 3 in Caenorhabditis elegans
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
top-3DNA topoisomerase 3 ; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] (759 aa)    
Predicted Functional Partners:
him-6
Bloom syndrome protein homolog ; Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3’-5’ direction (By similarity) (988 aa)
   
  0.997
T07C12.12
Uncharacterized protein (615 aa)
     
  0.979
K02F3.12
Putative ATP-dependent DNA helicase Q1 ; DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3’-5’ direction (By similarity) (631 aa)
   
  0.974
wrn-1
Probable Werner syndrome ATP-dependent helicase homolog 1 ; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA- helicase activity. May be involved in the control of genomic stability (By similarity) (1056 aa)
   
  0.963
Y50D4C.3
Protein Y50D4C.3 (605 aa)
     
 
  0.910
M01E11.3
Protein M01E11.3 (926 aa)
     
 
  0.909
rpa-1
Probable replication factor A 73 kDa subunit ; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (655 aa)
   
  0.889
rcq-5
ReCQ DNA helicase family member (rcq-5) (809 aa)
   
  0.870
Y116A8C.13
Uncharacterized protein (833 aa)
     
 
  0.830
rad-51
RADiation sensitivity abnormal/yeast RAD-related family member (rad-51) (395 aa)
   
 
  0.829
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, nematode
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