STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-13Nuclear hormone receptor family member nhr-13; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (425 aa)    
Predicted Functional Partners:
nhr-49
Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family.
    
 
0.749
spl-3
Sphingosine Phosphate Lyase.
      
 0.613
spl-2
Sphingosine Phosphate Lyase.
      
 0.534
cpt-5
Carn_acyltransf domain-containing protein.
      
 0.531
K05B2.4
Uncharacterized protein.
      
 0.530
mdt-15
Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...]
    
 
 0.491
ptr-16
SSD domain-containing protein.
      
 0.468
sbp-1
BHLH domain-containing protein.
      
 0.461
ptr-3
SSD domain-containing protein.
      
 0.420
C55B6.1
FGGY_C domain-containing protein.
   
   0.413
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.