STRINGSTRING
Y63D3A.4 protein (Caenorhabditis elegans) - STRING interaction network
"Y63D3A.4" - 5'-tyrosyl-DNA phosphodiesterase in Caenorhabditis elegans
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Y63D3A.45’-tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5’-phosphodiester bond, giving rise to DNA with a free 5’ phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5’- phosphoglycolates on protruding 5’ ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals (By similarity); Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily (362 aa)    
Predicted Functional Partners:
cku-70
Protein CKU-70 (cku-70) mRNA, complete cds (679 aa)
     
 
  0.912
cku-80
ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase (728 aa)
     
 
  0.907
atl-1
Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the c [...] (2531 aa)
     
 
    0.901
F52C12.1
Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3’-phosphodiester bond, giving rise to DNA with a free 3’ phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3’-phosphoglycolates on protruding 3’ ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3’exonuclease activity and may be able to remove a sing [...] (451 aa)
     
   
  0.899
exos-3
EXOSome (Multiexonuclease complex) component; Protein EXOS-3 (exos-3) mRNA, complete cds (226 aa)
     
      0.890
dis-3
Probable exosome complex exonuclease RRP44; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. dis-3 has both 3’-5’ exonuclease and endonuclease activities (By similarity) (961 aa)
     
      0.884
rnp-1
RNA-binding protein rnp-1; RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development (305 aa)
     
      0.803
exos-4.2
EXOSome (Multiexonuclease complex) component; Protein EXOS-4.2 (exos-4.2) mRNA, complete cds (241 aa)
     
      0.776
exos-4.1
Putative exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events; Belongs to the RNase PH family (240 aa)
     
      0.773
ser-1
SERotonin/octopamine receptor family; Protein SER-1, isoform a; Belongs to the G-protein coupled receptor 1 family (683 aa)
           
  0.728
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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