STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icd-2Nascent polypeptide-associated complex subunit alpha; May promote appropriate targeting of ribosome-nascent polypeptide complexes. (197 aa)    
Predicted Functional Partners:
icd-1
Transcription factor BTF3 homolog; May act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
   
 0.999
rpl-13
60S ribosomal protein L13.
   
   0.991
eef-1G
Probable elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.
   
 
 0.991
rpl-17
60S ribosomal protein L17.
   
 
 0.990
rpl-10
60S ribosomal protein L10.
  
   0.988
rpl-4
60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family.
   
 
 0.987
rpl-20
60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.
   
 
 0.986
rpl-5
60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]
   
 
 0.985
rpl-19
60S ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.
   
   0.984
rpl-21
60S ribosomal protein L21; Belongs to the eukaryotic ribosomal protein eL21 family.
   
   0.984
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.