Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| egl-17 | lag-2 | F38G1.2.1 | Y73C8B.4.1 | EGL-17; Belongs to the heparin-binding growth factors family. | Protein lag-2; Putative intercellular signal for lin-12 and GLP-1 receptors. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | 0.673 |
| egl-17 | lin-1 | F38G1.2.1 | C37F5.1a.1 | EGL-17; Belongs to the heparin-binding growth factors family. | ETS domain-containing protein. | 0.638 |
| egl-17 | lin-12 | F38G1.2.1 | R107.8.1 | EGL-17; Belongs to the heparin-binding growth factors family. | Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | 0.767 |
| egl-17 | lin-3 | F38G1.2.1 | F36H1.4f.1 | EGL-17; Belongs to the heparin-binding growth factors family. | Protein lin-3; Probable ligand for tyrosine kinase receptor let-23. Essential for vulval induction, where it acts downstream of the synthetic multivulva (synMuv) class genes. Probably by activating let-23, phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade, plays a role in ovulation by promoting gonadal sheath cell contractions and spermatheca dilatation during ovulation. Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, by [...] | 0.850 |
| egl-17 | lin-31 | F38G1.2.1 | K10G6.1.1 | EGL-17; Belongs to the heparin-binding growth factors family. | Protein lin-31; Lin-31 regulates how vulval precursor cells choose their fate. It helps specify three alternative cell fates in vulval development. | 0.698 |
| egl-17 | lin-39 | F38G1.2.1 | C07H6.7.2 | EGL-17; Belongs to the heparin-binding growth factors family. | Homeobox protein lin-39; Transcription factor that binds to the consensus 5'- TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression. Binds to the consensus PBC/Hox motif lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Regulates the expression of mig-13 which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts. This in turn controls the polarity migration of Q neuroblasts and the subsequent mid-body region-specific development. Belongs [...] | 0.707 |
| egl-43 | lag-2 | R53.3a.1 | Y73C8B.4.1 | Uncharacterized protein. | Protein lag-2; Putative intercellular signal for lin-12 and GLP-1 receptors. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | 0.670 |
| egl-43 | lin-12 | R53.3a.1 | R107.8.1 | Uncharacterized protein. | Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | 0.786 |
| egl-43 | lin-3 | R53.3a.1 | F36H1.4f.1 | Uncharacterized protein. | Protein lin-3; Probable ligand for tyrosine kinase receptor let-23. Essential for vulval induction, where it acts downstream of the synthetic multivulva (synMuv) class genes. Probably by activating let-23, phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade, plays a role in ovulation by promoting gonadal sheath cell contractions and spermatheca dilatation during ovulation. Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, by [...] | 0.660 |
| egl-43 | lin-31 | R53.3a.1 | K10G6.1.1 | Uncharacterized protein. | Protein lin-31; Lin-31 regulates how vulval precursor cells choose their fate. It helps specify three alternative cell fates in vulval development. | 0.550 |
| glp-1 | lag-1 | F02A9.6.1 | K08B4.1d.1 | Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. | Lin-12 And Glp-1 phenotype. | 0.953 |
| glp-1 | lag-2 | F02A9.6.1 | Y73C8B.4.1 | Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. | Protein lag-2; Putative intercellular signal for lin-12 and GLP-1 receptors. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | 0.626 |
| glp-1 | lin-12 | F02A9.6.1 | R107.8.1 | Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. | Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | 0.551 |
| glp-1 | sel-8 | F02A9.6.1 | C32A3.1a.1 | Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. | Protein lag-3; glp-1 and lin-12 promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator. May regulate phosphatase lip-1 mRNA transcription downstream of glp-1. | 0.661 |
| lag-1 | glp-1 | K08B4.1d.1 | F02A9.6.1 | Lin-12 And Glp-1 phenotype. | Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. | 0.953 |
| lag-1 | lag-2 | K08B4.1d.1 | Y73C8B.4.1 | Lin-12 And Glp-1 phenotype. | Protein lag-2; Putative intercellular signal for lin-12 and GLP-1 receptors. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | 0.809 |
| lag-1 | lin-12 | K08B4.1d.1 | R107.8.1 | Lin-12 And Glp-1 phenotype. | Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | 0.999 |
| lag-1 | lin-39 | K08B4.1d.1 | C07H6.7.2 | Lin-12 And Glp-1 phenotype. | Homeobox protein lin-39; Transcription factor that binds to the consensus 5'- TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression. Binds to the consensus PBC/Hox motif lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Regulates the expression of mig-13 which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts. This in turn controls the polarity migration of Q neuroblasts and the subsequent mid-body region-specific development. Belongs [...] | 0.476 |
| lag-1 | sel-8 | K08B4.1d.1 | C32A3.1a.1 | Lin-12 And Glp-1 phenotype. | Protein lag-3; glp-1 and lin-12 promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator. May regulate phosphatase lip-1 mRNA transcription downstream of glp-1. | 0.999 |
| lag-2 | egl-17 | Y73C8B.4.1 | F38G1.2.1 | Protein lag-2; Putative intercellular signal for lin-12 and GLP-1 receptors. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. | EGL-17; Belongs to the heparin-binding growth factors family. | 0.673 |
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