STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyn-7Peptidyl-prolyl cis-trans isomerase 7; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (171 aa)    
Predicted Functional Partners:
npp-11
Nuclear Pore complex Protein.
   
 
 0.875
ndk-1
Nucleoside diphosphate kinase; Belongs to the NDK family.
  
 
 0.858
rpl-2
60S ribosomal protein L8.
   
 
 0.736
hsp-90
Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...]
  
 
 0.716
cdkr-3
CDK5RAP3-like protein; Potential regulator of CDK5 activity.
      
 0.694
fkb-2
Peptidylprolyl isomerase.
  
 
 0.694
feh-1
Protein Fe65 homolog; Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2.
    
 
 0.690
rps-11
Ribosomal_S17_N domain-containing protein; Belongs to the universal ribosomal protein uS17 family.
   
   0.670
cpar-1
Histone H3-like centromeric protein cpar-1; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis.
   
 
 0.654
rpl-23
60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.
   
   0.648
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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