node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dnc-2 | plc-2 | C28H8.12.1 | Y75B12B.6.2 | Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. | Phosphoinositide phospholipase C. | 0.477 |
dnc-2 | pola-1 | C28H8.12.1 | Y47D3A.29b.1 | Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. | DNA polymerase. | 0.670 |
egl-30 | itr-1 | M01D7.7a.1 | F33D4.2a.1 | Heterotrimeric G protein alpha subunit. | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] | 0.731 |
egl-30 | plc-2 | M01D7.7a.1 | Y75B12B.6.2 | Heterotrimeric G protein alpha subunit. | Phosphoinositide phospholipase C. | 0.482 |
itr-1 | egl-30 | F33D4.2a.1 | M01D7.7a.1 | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] | Heterotrimeric G protein alpha subunit. | 0.731 |
itr-1 | plc-2 | F33D4.2a.1 | Y75B12B.6.2 | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] | Phosphoinositide phospholipase C. | 0.427 |
plc-2 | dnc-2 | Y75B12B.6.2 | C28H8.12.1 | Phosphoinositide phospholipase C. | Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. | 0.477 |
plc-2 | egl-30 | Y75B12B.6.2 | M01D7.7a.1 | Phosphoinositide phospholipase C. | Heterotrimeric G protein alpha subunit. | 0.482 |
plc-2 | itr-1 | Y75B12B.6.2 | F33D4.2a.1 | Phosphoinositide phospholipase C. | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] | 0.427 |
plc-2 | pola-1 | Y75B12B.6.2 | Y47D3A.29b.1 | Phosphoinositide phospholipase C. | DNA polymerase. | 0.485 |
plc-2 | sos-1 | Y75B12B.6.2 | T28F12.3.1 | Phosphoinositide phospholipase C. | Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] | 0.685 |
pola-1 | dnc-2 | Y47D3A.29b.1 | C28H8.12.1 | DNA polymerase. | Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. | 0.670 |
pola-1 | plc-2 | Y47D3A.29b.1 | Y75B12B.6.2 | DNA polymerase. | Phosphoinositide phospholipase C. | 0.485 |
sos-1 | plc-2 | T28F12.3.1 | Y75B12B.6.2 | Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] | Phosphoinositide phospholipase C. | 0.685 |