STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Y75B8A.24Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2106 aa)    
Predicted Functional Partners:
ZC8.6
PI3K/PI4K domain-containing protein.
    
 0.991
C56A3.8
PI3K/PI4K domain-containing protein.
    
 0.990
ppk-1
PIPK domain-containing protein.
   
 0.987
pisy-1
CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
   
 
 0.984
sac-1
SAC domain-containing protein.
   
 0.980
pifk-1
PhosphoInositide Four Kinase (PI-4 Kinase); Belongs to the PI3/PI4-kinase family.
    
0.979
ppk-3
PIP Kinase.
   
 
 0.963
ttc-7
TPR_REGION domain-containing protein.
    
 
 0.961
unc-26
Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family.
   
 
 0.943
vps-34
Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...]
     
0.921
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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