Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cul-2 | cul-5 | ZK520.4c.1 | ZK856.1.1 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | 0.908 |
| cul-2 | elb-1 | ZK520.4c.1 | Y41C4A.10.1 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | RNA polymerase II transcription factor SIII p18 subunit. | 0.999 |
| cul-2 | elc-1 | ZK520.4c.1 | Y82E9BR.15.1 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | Skp1_POZ domain-containing protein. | 0.999 |
| cul-2 | lrr-1 | ZK520.4c.1 | F33G12.4.1 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | Leucine-Rich Repeat protein. | 0.999 |
| cul-2 | ned-8 | ZK520.4c.1 | F45H11.2.1 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | 0.995 |
| cul-2 | rbx-1 | ZK520.4c.1 | ZK287.5.2 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.999 |
| cul-2 | rbx-2 | ZK520.4c.1 | R10A10.2.1 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | RING-type domain-containing protein. | 0.995 |
| cul-2 | tceb-3 | ZK520.4c.1 | R03D7.4.1 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | Transcription elongation factor B polypeptide 3; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). | 0.754 |
| cul-2 | vhl-1 | ZK520.4c.1 | F08G12.4.1 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | Von Hippel-Lindau tumor suppressor homolog; Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size. Mediates resistance to enteropathogenic E.coli. Mediates susceptibility to B.thuringiensis pore-forming toxins. Not involved in P.aeruginosa susceptibility. Belongs to the VHL family. | 0.995 |
| cul-2 | zyg-11 | ZK520.4c.1 | C08B11.1.2 | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | Early embryogenesis protein zyg-11; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment. | 0.991 |
| cul-5 | cul-2 | ZK856.1.1 | ZK520.4c.1 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | 0.908 |
| cul-5 | elb-1 | ZK856.1.1 | Y41C4A.10.1 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | RNA polymerase II transcription factor SIII p18 subunit. | 0.999 |
| cul-5 | elc-1 | ZK856.1.1 | Y82E9BR.15.1 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | Skp1_POZ domain-containing protein. | 0.999 |
| cul-5 | lrr-1 | ZK856.1.1 | F33G12.4.1 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | Leucine-Rich Repeat protein. | 0.573 |
| cul-5 | ned-8 | ZK856.1.1 | F45H11.2.1 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. | 0.998 |
| cul-5 | rbx-1 | ZK856.1.1 | ZK287.5.2 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. | 0.999 |
| cul-5 | rbx-2 | ZK856.1.1 | R10A10.2.1 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | RING-type domain-containing protein. | 0.999 |
| cul-5 | tceb-3 | ZK856.1.1 | R03D7.4.1 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | Transcription elongation factor B polypeptide 3; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). | 0.914 |
| cul-5 | vhl-1 | ZK856.1.1 | F08G12.4.1 | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. | Von Hippel-Lindau tumor suppressor homolog; Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size. Mediates resistance to enteropathogenic E.coli. Mediates susceptibility to B.thuringiensis pore-forming toxins. Not involved in P.aeruginosa susceptibility. Belongs to the VHL family. | 0.501 |
| elb-1 | cul-2 | Y41C4A.10.1 | ZK520.4c.1 | RNA polymerase II transcription factor SIII p18 subunit. | Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...] | 0.999 |
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