node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cle-1 | emb-9 | C36B1.1d.1 | K04H4.1a.1 | CoLlagen with Endostatin domain. | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | 0.416 |
cle-1 | let-2 | C36B1.1d.1 | F01G12.5b.1 | CoLlagen with Endostatin domain. | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | 0.420 |
cle-1 | nid-1 | C36B1.1d.1 | F54F3.1a.1 | CoLlagen with Endostatin domain. | NIDogen (Basement membrane protein). | 0.900 |
cle-1 | unc-52 | C36B1.1d.1 | ZC101.2e.1 | CoLlagen with Endostatin domain. | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. | 0.861 |
emb-9 | cle-1 | K04H4.1a.1 | C36B1.1d.1 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | CoLlagen with Endostatin domain. | 0.416 |
emb-9 | let-2 | K04H4.1a.1 | F01G12.5b.1 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | 0.967 |
emb-9 | myo-3 | K04H4.1a.1 | K12F2.1.1 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.645 |
emb-9 | nid-1 | K04H4.1a.1 | F54F3.1a.1 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | NIDogen (Basement membrane protein). | 0.814 |
emb-9 | pat-2 | K04H4.1a.1 | F54F2.1.1 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...] | 0.880 |
emb-9 | pat-3 | K04H4.1a.1 | ZK1058.2.1 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] | 0.903 |
emb-9 | unc-52 | K04H4.1a.1 | ZC101.2e.1 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. | 0.900 |
emb-9 | unc-54 | K04H4.1a.1 | F11C3.3.2 | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.653 |
let-2 | cle-1 | F01G12.5b.1 | C36B1.1d.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | CoLlagen with Endostatin domain. | 0.420 |
let-2 | emb-9 | F01G12.5b.1 | K04H4.1a.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons. | 0.967 |
let-2 | mec-8 | F01G12.5b.1 | F46A9.6.3 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Mec-8 protein. | 0.636 |
let-2 | myo-3 | F01G12.5b.1 | K12F2.1.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.674 |
let-2 | nid-1 | F01G12.5b.1 | F54F3.1a.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | NIDogen (Basement membrane protein). | 0.862 |
let-2 | pat-2 | F01G12.5b.1 | F54F2.1.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...] | 0.575 |
let-2 | pat-3 | F01G12.5b.1 | ZK1058.2.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] | 0.938 |
let-2 | unc-52 | F01G12.5b.1 | ZC101.2e.1 | Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development. | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. | 0.922 |