STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
morc-1Protein morc-1; Involved in gene silencing. Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes. May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes. Promotes transgenerational epigenetic inheritance and germline immortality. (845 aa)    
Predicted Functional Partners:
hpo-32
Uncharacterized protein.
   
  
 0.855
set-32
SET domain-containing protein.
   
 
 0.831
hrde-1
Uncharacterized protein C16C10.3.
   
  
 0.822
hrde-2
Protein hrde-2; Plays a role in germline RNA interference (RNAi), and in particular is required for piwi-interacting RNA (piRNA) gene silencing. Facilitates the binding of the argonaut protein hrde-1 to small interfering RNAs (siRNAs) targets that are required for transgenerational epigenetic inheritance and germline immortality.
   
  
 0.810
F44D12.6
Uncharacterized protein.
      
 0.809
Y41C4A.7
Uncharacterized protein.
      
 0.809
set-25
Histone-lysine N-methyltransferase set-25; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription- induced replication stress through methylation of H3K9.
   
 
 0.724
hrde-4
Protein hrde-4; May play a role in transgenerational epigenetic inheritance.
   
  
 0.703
nrde-4
Uncharacterized protein.
   
  
 0.694
nrde-1
Uncharacterized protein.
   
  
 0.673
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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