node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F32D1.5 | T19B4.3 | F32D1.5a.1 | T19B4.3.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.960 |
F32D1.5 | T22D1.3 | F32D1.5a.1 | T22D1.3a.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.942 |
F32D1.5 | adss-1 | F32D1.5a.1 | C37H5.6a.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | 0.997 |
F32D1.5 | cat-4 | F32D1.5a.1 | F32G8.6.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GTP cyclohydrolase 1; Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration. | 0.436 |
F32D1.5 | dut-1 | F32D1.5a.1 | K07A1.2.3 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Deoxyuridinetriphosphatase. | 0.489 |
F32D1.5 | gmps-1 | F32D1.5a.1 | M106.4b.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Probable GMP synthase [glutamine-hydrolyzing]. | 0.998 |
F32D1.5 | guk-1 | F32D1.5a.1 | T03F1.8a.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Guanylate kinase-like domain-containing protein. | 0.932 |
F32D1.5 | hap-1 | F32D1.5a.1 | ZC395.7.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.956 |
R05G6.5 | T19B4.3 | R05G6.5.1 | T19B4.3.1 | Uncharacterized protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.495 |
R05G6.5 | adss-1 | R05G6.5.1 | C37H5.6a.1 | Uncharacterized protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | 0.488 |
R05G6.5 | cat-4 | R05G6.5.1 | F32G8.6.1 | Uncharacterized protein. | GTP cyclohydrolase 1; Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration. | 0.847 |
R05G6.5 | dut-1 | R05G6.5.1 | K07A1.2.3 | Uncharacterized protein. | Deoxyuridinetriphosphatase. | 0.984 |
R05G6.5 | gmps-1 | R05G6.5.1 | M106.4b.1 | Uncharacterized protein. | Probable GMP synthase [glutamine-hydrolyzing]. | 0.477 |
R05G6.5 | guk-1 | R05G6.5.1 | T03F1.8a.1 | Uncharacterized protein. | Guanylate kinase-like domain-containing protein. | 0.955 |
R05G6.5 | hap-1 | R05G6.5.1 | ZC395.7.1 | Uncharacterized protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.982 |
R05G6.5 | ndk-1 | R05G6.5.1 | F25H2.5.1 | Uncharacterized protein. | Nucleoside diphosphate kinase; Belongs to the NDK family. | 0.909 |
T19B4.3 | F32D1.5 | T19B4.3.1 | F32D1.5a.1 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.960 |
T19B4.3 | R05G6.5 | T19B4.3.1 | R05G6.5.1 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Uncharacterized protein. | 0.495 |
T19B4.3 | T22D1.3 | T19B4.3.1 | T22D1.3a.1 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.679 |
T19B4.3 | adss-1 | T19B4.3.1 | C37H5.6a.1 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | 0.854 |