STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nekl-2Serine/threonine-protein kinase nekl-2; Probable serine/threonine-protein kinase required for the completion of molting. May play a role in endocytosis in the hypodermis syncytium. (357 aa)    
Predicted Functional Partners:
mlt-3
ANK_REP_REGION domain-containing protein.
   
 
 0.881
mlt-4
ANK_REP_REGION domain-containing protein.
   
 
 0.872
mlt-2
ANK_REP_REGION domain-containing protein.
   
 
 0.824
C27F2.9
JmjC domain-containing protein.
      
 0.741
pdhk-2
Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
      
 0.740
adm-2
ADAM (Disintegrin plus metalloprotease) family.
      
 0.660
ncap-1
DUF1681 domain-containing protein.
      
 0.620
col-14
Cuticle collagen 14; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
      
 0.610
nekl-3
Serine/threonine-protein kinase nekl-3; Probable serine/threonine-protein kinase required for the completion of molting; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
  
 
0.500
lrp-1
Low-density lipoprotein receptor-related protein; May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease-inhibitor complexes and vitellogenin; Belongs to the LDLR family.
   
  
 0.474
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (26%) [HD]