node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ceh-10 | cho-1 | W03A3.1.1 | C48D1.3.1 | Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons. | High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. | 0.592 |
ceh-10 | lim-4 | W03A3.1.1 | ZC64.4a.1 | Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons. | Putative transcription factor LIM-4. | 0.687 |
ceh-10 | unc-3 | W03A3.1.1 | Y16B4A.1.1 | Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons. | Transcription factor unc-3; May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. | 0.771 |
ceh-24 | lim-4 | F55B12.1.1 | ZC64.4a.1 | Homeobox protein ceh-24; Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left- right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis. | Putative transcription factor LIM-4. | 0.631 |
ceh-36 | lim-4 | C37E2.4.1 | ZC64.4a.1 | Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. | Putative transcription factor LIM-4. | 0.768 |
ceh-36 | mls-2 | C37E2.4.1 | C39E6.4.1 | Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. | Homeobox domain-containing protein. | 0.829 |
ceh-36 | odr-7 | C37E2.4.1 | T18D3.2.1 | Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. | Nuclear hormone receptor family member odr-7; Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity. | 0.812 |
ceh-36 | str-1 | C37E2.4.1 | C42D4.5.1 | Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. | Seven TM Receptor. | 0.690 |
cho-1 | ceh-10 | C48D1.3.1 | W03A3.1.1 | High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. | Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons. | 0.592 |
cho-1 | lim-4 | C48D1.3.1 | ZC64.4a.1 | High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. | Putative transcription factor LIM-4. | 0.660 |
cho-1 | unc-3 | C48D1.3.1 | Y16B4A.1.1 | High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. | Transcription factor unc-3; May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. | 0.763 |
ldb-1 | lim-4 | F58A3.1c.1 | ZC64.4a.1 | LID domain-containing protein. | Putative transcription factor LIM-4. | 0.738 |
lim-4 | ceh-10 | ZC64.4a.1 | W03A3.1.1 | Putative transcription factor LIM-4. | Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons. | 0.687 |
lim-4 | ceh-24 | ZC64.4a.1 | F55B12.1.1 | Putative transcription factor LIM-4. | Homeobox protein ceh-24; Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left- right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis. | 0.631 |
lim-4 | ceh-36 | ZC64.4a.1 | C37E2.4.1 | Putative transcription factor LIM-4. | Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. | 0.768 |
lim-4 | cho-1 | ZC64.4a.1 | C48D1.3.1 | Putative transcription factor LIM-4. | High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent. | 0.660 |
lim-4 | ldb-1 | ZC64.4a.1 | F58A3.1c.1 | Putative transcription factor LIM-4. | LID domain-containing protein. | 0.738 |
lim-4 | mls-2 | ZC64.4a.1 | C39E6.4.1 | Putative transcription factor LIM-4. | Homeobox domain-containing protein. | 0.684 |
lim-4 | odr-7 | ZC64.4a.1 | T18D3.2.1 | Putative transcription factor LIM-4. | Nuclear hormone receptor family member odr-7; Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity. | 0.818 |
lim-4 | str-1 | ZC64.4a.1 | C42D4.5.1 | Putative transcription factor LIM-4. | Seven TM Receptor. | 0.660 |