node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Y76A2B.5 | cblc-1 | Y76A2B.5.2 | ZK546.17.1 | Uncharacterized protein. | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | 0.793 |
Y76A2B.5 | mce-1 | Y76A2B.5.2 | D2030.5.1 | Uncharacterized protein. | Mitochondrial methylmalonyl-CoA epimerase. | 0.820 |
Y76A2B.5 | metr-1 | Y76A2B.5.2 | R03D7.1.1 | Uncharacterized protein. | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.959 |
Y76A2B.5 | mmaa-1 | Y76A2B.5.2 | T02G5.13a.1 | Uncharacterized protein. | Methylmalonic aciduria type A homolog, mitochondrial; May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity). Likely to have a role in propionyl-CoA metabolism and adenosylcobalamin synthesis. | 0.677 |
Y76A2B.5 | mmab-1 | Y76A2B.5.2 | C26E6.11.1 | Uncharacterized protein. | Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.671 |
Y76A2B.5 | mmcm-1 | Y76A2B.5.2 | ZK1058.1.1 | Uncharacterized protein. | Probable methylmalonyl-CoA mutase, mitochondrial; Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity). | 0.936 |
cblc-1 | Y76A2B.5 | ZK546.17.1 | Y76A2B.5.2 | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | Uncharacterized protein. | 0.793 |
cblc-1 | mce-1 | ZK546.17.1 | D2030.5.1 | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | Mitochondrial methylmalonyl-CoA epimerase. | 0.861 |
cblc-1 | metr-1 | ZK546.17.1 | R03D7.1.1 | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.755 |
cblc-1 | mmaa-1 | ZK546.17.1 | T02G5.13a.1 | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | Methylmalonic aciduria type A homolog, mitochondrial; May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity). Likely to have a role in propionyl-CoA metabolism and adenosylcobalamin synthesis. | 0.978 |
cblc-1 | mmab-1 | ZK546.17.1 | C26E6.11.1 | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.977 |
cblc-1 | mmcm-1 | ZK546.17.1 | ZK1058.1.1 | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | Probable methylmalonyl-CoA mutase, mitochondrial; Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity). | 0.916 |
mce-1 | Y76A2B.5 | D2030.5.1 | Y76A2B.5.2 | Mitochondrial methylmalonyl-CoA epimerase. | Uncharacterized protein. | 0.820 |
mce-1 | cblc-1 | D2030.5.1 | ZK546.17.1 | Mitochondrial methylmalonyl-CoA epimerase. | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | 0.861 |
mce-1 | metr-1 | D2030.5.1 | R03D7.1.1 | Mitochondrial methylmalonyl-CoA epimerase. | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.829 |
mce-1 | mmaa-1 | D2030.5.1 | T02G5.13a.1 | Mitochondrial methylmalonyl-CoA epimerase. | Methylmalonic aciduria type A homolog, mitochondrial; May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity). Likely to have a role in propionyl-CoA metabolism and adenosylcobalamin synthesis. | 0.917 |
mce-1 | mmab-1 | D2030.5.1 | C26E6.11.1 | Mitochondrial methylmalonyl-CoA epimerase. | Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.886 |
mce-1 | mmcm-1 | D2030.5.1 | ZK1058.1.1 | Mitochondrial methylmalonyl-CoA epimerase. | Probable methylmalonyl-CoA mutase, mitochondrial; Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity). | 0.994 |
metr-1 | Y76A2B.5 | R03D7.1.1 | Y76A2B.5.2 | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | Uncharacterized protein. | 0.959 |
metr-1 | cblc-1 | R03D7.1.1 | ZK546.17.1 | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...] | 0.755 |