STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htas-1Histone H2A; Belongs to the histone H2A family. (145 aa)    
Predicted Functional Partners:
Y106G6A.4
Uncharacterized protein.
   
    0.995
smz-2
Sperm Meiosis PDZ domain containing proteins.
   
 
 0.970
C34D4.3
MSP domain-containing protein.
   
    0.941
smz-1
Sperm Meiosis PDZ domain containing proteins.
   
 
 0.911
his-70
Histone H3.3-like type 1; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
   
 
 0.882
spch-1
SPerm CHromatin enriched.
   
  
 0.878
comp-1
Protein kinase domain-containing protein.
   
  
 0.872
C27D6.3
Uncharacterized protein C27D6.3.
   
    0.870
rmd-3
Regulator of Microtubule Dynamics.
   
    0.846
C24D10.2
Uncharacterized protein.
   
    0.846
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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