STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
riok-3Serine/threonine-protein kinase RIO3. (510 aa)    
Predicted Functional Partners:
tag-151
Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
   
 0.973
pno-1
RNA-binding protein pno-1.
   
 0.955
Y54E10BR.4
RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family.
   
 0.949
T23D8.3
Protein LTV1 homolog; Belongs to the LTV1 family.
   
 0.927
riok-2
Serine/threonine-protein kinase RIO2; Required for larval development. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
   
 
0.924
rps-30
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
   0.856
byn-1
Uncharacterized protein byn-1; Belongs to the bystin family.
   
 0.854
eif-1.A
S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
  
 
 0.828
prmt-5
Protein arginine N-methyltransferase 5; Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group. Plays a role in the negative regulation of DNA damage-induced apoptosis. By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell [...]
   
 
 0.807
rps-3
40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.
   
 0.800
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.