node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
T08E11.8 | ZK652.6 | T08E11.8.1 | ZK652.6a.1 | Uncharacterized protein. | Uncharacterized protein ZK652.6. | 0.420 |
ZK652.6 | T08E11.8 | ZK652.6a.1 | T08E11.8.1 | Uncharacterized protein ZK652.6. | Uncharacterized protein. | 0.420 |
ZK652.6 | cul-3 | ZK652.6a.1 | Y108G3AL.1a.3 | Uncharacterized protein ZK652.6. | Cullin-3; Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule st [...] | 0.486 |
ZK652.6 | etc-1 | ZK652.6a.1 | D2085.4.1 | Uncharacterized protein ZK652.6. | E3 ubiquitin-protein ligase etc-1; E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos. | 0.562 |
ZK652.6 | him-17 | ZK652.6a.1 | T09E8.2.1 | Uncharacterized protein ZK652.6. | High Incidence of Males (Increased X chromosome loss). | 0.439 |
ZK652.6 | hrpk-1 | ZK652.6a.1 | F26B1.2a.1 | Uncharacterized protein ZK652.6. | Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response. | 0.403 |
ZK652.6 | ppm-1.A | ZK652.6a.1 | F25D1.1a.1 | Uncharacterized protein ZK652.6. | Protein phosphatase ppm-1.A; Probable phosphatase which regulates axon termination in ALM and PLM neurons, and synaptic branch extension and/or stabilization in PLM neurons. Plays a role in synapse formation in GABAergic DD motor neurons probably by dephosphorylating pmk-3 thereby negatively regulating a MAP kinase pathway that includes dlk-1, mkk-4 and pmk-3. Belongs to the PP2C family. | 0.439 |
ZK652.6 | ubql-1 | ZK652.6a.1 | F15C11.2a.1 | Uncharacterized protein ZK652.6. | Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] | 0.411 |
ZK652.6 | ubr-4 | ZK652.6a.1 | C44E4.1d.1 | Uncharacterized protein ZK652.6. | UBR-type domain-containing protein. | 0.928 |
cul-3 | ZK652.6 | Y108G3AL.1a.3 | ZK652.6a.1 | Cullin-3; Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule st [...] | Uncharacterized protein ZK652.6. | 0.486 |
etc-1 | ZK652.6 | D2085.4.1 | ZK652.6a.1 | E3 ubiquitin-protein ligase etc-1; E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos. | Uncharacterized protein ZK652.6. | 0.562 |
him-17 | ZK652.6 | T09E8.2.1 | ZK652.6a.1 | High Incidence of Males (Increased X chromosome loss). | Uncharacterized protein ZK652.6. | 0.439 |
hrpk-1 | ZK652.6 | F26B1.2a.1 | ZK652.6a.1 | Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response. | Uncharacterized protein ZK652.6. | 0.403 |
hrpk-1 | ubql-1 | F26B1.2a.1 | F15C11.2a.1 | Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response. | Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] | 0.515 |
ppm-1.A | ZK652.6 | F25D1.1a.1 | ZK652.6a.1 | Protein phosphatase ppm-1.A; Probable phosphatase which regulates axon termination in ALM and PLM neurons, and synaptic branch extension and/or stabilization in PLM neurons. Plays a role in synapse formation in GABAergic DD motor neurons probably by dephosphorylating pmk-3 thereby negatively regulating a MAP kinase pathway that includes dlk-1, mkk-4 and pmk-3. Belongs to the PP2C family. | Uncharacterized protein ZK652.6. | 0.439 |
ubql-1 | ZK652.6 | F15C11.2a.1 | ZK652.6a.1 | Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] | Uncharacterized protein ZK652.6. | 0.411 |
ubql-1 | hrpk-1 | F15C11.2a.1 | F26B1.2a.1 | Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...] | Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response. | 0.515 |
ubr-4 | ZK652.6 | C44E4.1d.1 | ZK652.6a.1 | UBR-type domain-containing protein. | Uncharacterized protein ZK652.6. | 0.928 |