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let-60 protein (Caenorhabditis elegans) - STRING interaction network
"let-60" - Ras protein let-60 in Caenorhabditis elegans
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second shell of interactors
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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let-60Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1; Belongs to the small GTPase superfamily. Ras family (184 aa)    
Predicted Functional Partners:
lin-45
Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Positively regulates lifespan upstream of mek-2 and mpk-1 (813 aa)
     
  0.999
sos-1
Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa)
     
  0.999
let-23
Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades- the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] (1328 aa)
       
  0.999
mpk-1
Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] (444 aa)
     
  0.999
sem-5
Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl-15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the l [...] (228 aa)
     
  0.998
rgl-1
Ral GDS-Like; Protein RGL-1, isoform b (rgl-1) mRNA, complete cds (880 aa)
     
  0.998
mek-2
Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1 (387 aa)
     
  0.998
gap-1
Ras GTPase-activating protein gap-1; GTPase-activating protein, which inhibits the vulval induction by acting as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras (629 aa)
     
  0.987
ptp-2
Tyrosine-protein phosphatase non-receptor type ptp-2; Involved in embryonic and larval development. Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15. Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1. Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23. N [...] (668 aa)
     
  0.987
pxf-1
Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle; Belongs to the RAPGEF2 family (1470 aa)
     
  0.986
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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