node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
W09B6.4 | Y57G11C.43 | W09B6.4c.1 | Y57G11C.43.1 | Uncharacterized protein. | Uncharacterized protein. | 0.833 |
W09B6.4 | dph-3 | W09B6.4c.1 | K01H12.1a.1 | Uncharacterized protein. | DPH3 homolog; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). | 0.537 |
W09B6.4 | elpc-1 | W09B6.4c.1 | Y110A7A.16.1 | Uncharacterized protein. | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | 0.976 |
W09B6.4 | elpc-2 | W09B6.4c.1 | Y111B2A.17.2 | Uncharacterized protein. | ELongator complex Protein Component. | 0.967 |
W09B6.4 | elpc-3 | W09B6.4c.1 | ZK863.3.1 | Uncharacterized protein. | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] | 0.973 |
W09B6.4 | elpc-4 | W09B6.4c.1 | C26B2.6.1 | Uncharacterized protein. | Putative elongator complex protein 4; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the ELP4 family. | 0.994 |
W09B6.4 | mcm-5 | W09B6.4c.1 | R10E4.4.2 | Uncharacterized protein. | DNA replication licensing factor mcm-5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] | 0.534 |
W09B6.4 | tut-1 | W09B6.4c.1 | F29C4.6.1 | Uncharacterized protein. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position; Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily. | 0.765 |
Y57G11C.43 | W09B6.4 | Y57G11C.43.1 | W09B6.4c.1 | Uncharacterized protein. | Uncharacterized protein. | 0.833 |
Y57G11C.43 | dph-3 | Y57G11C.43.1 | K01H12.1a.1 | Uncharacterized protein. | DPH3 homolog; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). | 0.677 |
Y57G11C.43 | elpc-1 | Y57G11C.43.1 | Y110A7A.16.1 | Uncharacterized protein. | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | 0.850 |
Y57G11C.43 | elpc-2 | Y57G11C.43.1 | Y111B2A.17.2 | Uncharacterized protein. | ELongator complex Protein Component. | 0.873 |
Y57G11C.43 | elpc-3 | Y57G11C.43.1 | ZK863.3.1 | Uncharacterized protein. | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] | 0.930 |
Y57G11C.43 | elpc-4 | Y57G11C.43.1 | C26B2.6.1 | Uncharacterized protein. | Putative elongator complex protein 4; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the ELP4 family. | 0.734 |
Y57G11C.43 | mcm-5 | Y57G11C.43.1 | R10E4.4.2 | Uncharacterized protein. | DNA replication licensing factor mcm-5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] | 0.814 |
Y57G11C.43 | tsp-17 | Y57G11C.43.1 | C02F12.1b.1 | Uncharacterized protein. | Tetraspanin-17; Protects dopaminergic neurons against oxidative stress- induced neurodegeneration. May act partly via dopamine receptor dop-2 to negatively regulate dopamine reuptake transporter dat-1 activity. Also plays a role in modulating behaviors linked to dopamine signaling. Confers protection against oxidative stress in the whole body. | 0.572 |
Y57G11C.43 | tut-1 | Y57G11C.43.1 | F29C4.6.1 | Uncharacterized protein. | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position; Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily. | 0.632 |
Y57G11C.43 | tut-2 | Y57G11C.43.1 | F29F11.3.1 | Uncharacterized protein. | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position. | 0.436 |
dph-3 | W09B6.4 | K01H12.1a.1 | W09B6.4c.1 | DPH3 homolog; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). | Uncharacterized protein. | 0.537 |
dph-3 | Y57G11C.43 | K01H12.1a.1 | Y57G11C.43.1 | DPH3 homolog; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). | Uncharacterized protein. | 0.677 |