STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cheA3Chemotaxis histidine kinase protein,ATPbind_ATPase. IPR004358; Bact_sens_pr_C. IPR002545; CheW. IPR004105; H-kinase_dim. IPR005467; His_kinase. IPR008207; Hpt. IPR008208; Hpt_N. Pfam: PF01584; CheW. PF02895; H-kinase_dim. PF02518; HATPase_c. PF01627; Hpt. SMART: SM00260; CheW. SM00387; HATPase_c. SM00073; HPT. Chemotaxis protein cheA (EC 2.7.3.-). INVOLVED IN THE TRANSMISSION OF SENSORY SIGNALS FROM THE CHEMORECEPTORS TO THE FLAGELLAR MOTORS. CHEA IS AUTOPHOSPHORYLATED; IT CAN TRANSFER ITS PHOSPHATE GROUP TO EITHER CHEB OR CHEY; High confidence in function and specificity. (631 aa)    
Predicted Functional Partners:
cheV2
Probable chemotaxis protein, CheW. IPR001789; Response_reg. Pfam: PF01584; CheW. PF00072; Response_reg. SMART: SM00260; CheW. SM00448; REC. Chemotaxis protein cheV. CHEMOTAXIS INVOLVES BOTH A PHOSPHORYLATION-DEPENDENT EXCITATION AND A METHYLATION-DEPENDENT ADAPTATION. CHEV AND CHEW FUNCTION TOGETHER TO COUPLE CHEA ACTIVATION TO METHYL-ACCEPTING CHEMOTAXIS PROTEIN RECEPTOR STATUS AND POSSIBLE CHEA-DEPENDENT PHOSPHORYLATION OF CHEV CONTRIBUTES TO ADAPTATION; High confidence in function and specificity.
 
 0.995
cheB2
Protein glutamate-methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 0.990
cheZ
Chemotaxis protein CheZ,; High confidence in function and specificity.
  
 0.990
cheV1
Probable chemotaxis protein, CheW. IPR001789; Response_reg. Pfam: PF01584; CheW. PF00072; Response_reg. SMART: SM00260; CheW. SM00448; REC. Chemotaxis protein cheV. CHEMOTAXIS INVOLVES BOTH A PHOSPHORYLATION-DEPENDENT EXCITATION AND A METHYLATION-DEPENDENT ADAPTATION. CHEV AND CHEW FUNCTION TOGETHER TO COUPLE CHEA ACTIVATION TO METHYL-ACCEPTING CHEMOTAXIS PROTEIN RECEPTOR STATUS AND POSSIBLE CHEA-DEPENDENT PHOSPHORYLATION OF CHEV CONTRIBUTES TO ADAPTATION; High confidence in function and specificity.
 
 0.989
cheB1
Probable protein glutamate-methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 0.988
cheW2
Positive regulator of CheA protein activity,; High confidence in function and specificity.
 
 0.988
cheW1
Probable positive regulator of CheA protein activity, CheW. Pfam: PF01584; CheW. SMART: SM00260; CheW. Chemotaxis protein cheW.Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges chea to the mcps (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to cheY and cheB; High confidence in function and specificity.
 
 0.986
cheY3
Chemotaxis response regulator, Response_reg. Pfam: PF00072; Response_reg. SMART: SM00448; REC. Chemotaxis protein cheY. Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form cheY exhibits enhanced binding to a switch component fliM at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity); High confidence in function and specificity.
 
 0.982
tcp
Putative citrate chemoreceptor protein; Salmonella typhimurium shows an attractant response to citrate and a repellent response to phenol, and a chemoreceptor mediating these responses has been identified and named Tcp (taxis to citrate and away from phenol). Similar to sprot|MCPC_SALTY (32%)and to trembl|Q82TM2. InterPro (IPR004089): Bacterial chemotaxis sensory transducer InterPro (IPR003660): HAMP InterPro (IPR004090): Methyl-accepting chemotaxis protein InterPro (IPR001610): PAC InterPro (IPR000014): PAS_domain Pfam (PF00672): HAMP Pfam (PF00015): MCPsignal Pfam (PF00785): PAC Pfam [...]
 
 0.967
cheR2
Chemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
 
 
 0.967
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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