STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (228 aa)    
Predicted Functional Partners:
bioA
Adenosylmethionine--8-amino-7-oxononanoate transaminase; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA aminotransferase). TGIRFAM: bioA: adenosylmethionine--8-amino-7-oxononanoate transaminase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.999
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
 
 0.998
bioF
8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
 
 
 0.995
bioC1
Biotin synthesis protein bioC. bioc is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin; Specificity unclear.
 
 
 0.935
bioH
BioH protein.Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). Seems to be implicated in the early steps of biotin biosynthesis; Function unclear.
 
 
 0.871
azo0213
Aminotransferase, class III; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (78-diamino-pelargonic acid aminotransferase) (DAPA aminotransferase). bioA: adenosylmethionine--8-amino-7-oxononanoate aminotransferase; Specificity unclear; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.853
azo2100
Beta-alanine--pyruvate transaminase; Omega-amino acid--pyruvate aminotransferase (Omega-APT) (Beta-alanine--pyruvate aminotransferase). Catalyzes transamination between a variety of omega- amino acids,mono and diamines, and pyruvate, by similarity. InterPro: Aminotransferase class-III pyridoxal-phosphate TIGRFAM: bioA: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.837
bioC2
Putative biotin synthesis protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
 
 
 0.677
birA
biotin--[acetyl-CoA-carboxylase] ligase; BirA bifunctional protein [Includes: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15) (Biotin--protein ligase)]. birA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-coa:carbon- dioxide ligase. this protein also activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins. InterPro: Biotin--acetyl-CoA-carboxylase ligase birA_ligase: biotin--acetyl-CoA-carboxyla; Specificity unclear.
  
  
 0.639
azo1887
Conserved hypothetical protein. Homology to RS03577 of R.solanacearum of 66% (tremble:Q8XXV4). Has PF03883,Protein of unknown function (DUF328); IPR005583; Members of this family are functionally uncharacterised. They are about 250 amino acids in length. No signal peptide. No TMHs; Belongs to the UPF0246 family.
       0.614
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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