STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccmGProbable thiol disulfide interchange protein. Involved in disulfide bond formation. Catalyzes a late reductive step in the assembly of periplasmic c-type cytochromes probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity). InterPro: Periplasmic protein thiol:disulfide oxidoreductase DsbE (IPR004799) Interpro: Thioredoxin (IPR006662) Tigrfam: dsbE: periplasmic protein thiol:disulfide axidoreductase, DsbE superfamily signal peptide Probable 1 TMH; Family membership. (197 aa)    
Predicted Functional Partners:
ccmF
Cytochrome c-type biogenesis protein ccmF. Homology to ccmF of E. coli of 63% (sprot|CCMF_ECOLI). REQUIRED FOR THE BIOGENESIS OF C-TYPE CYTOCHROMES. POSSIBLE SUBUNIT OF A HEME LYASE. Tigrfam: nerF: cytochrome c-type biogenesis protein ccmF Pfam: Cytochrome C assembly protein probably signal peptide probably 15 THMs; High confidence in function and specificity.
 
  
 0.994
cycH
Conserved hyppthetical cytochrome c-type biogenesis protein CycH. Homology to cycH of Azoarcus sp. EbN1 of 50% (gnl|keqq|eba:ebA3526(KEGG)). REQUIRED FOR THE BIOGENESIS OF C-TYPE CYTOCHROMES. POSSIBLE SUBUNIT OF A HEME LYASE (BY SIMILARITY). signal peptide. 1 TMHs; Conserved hypothetical protein.
 
  
 0.986
cycL
Probable cytochrome C-type biogenesis protein CycL; Possible subunit of a heme lyase.
 
  
 0.978
ccmE
Probable cytochrome C-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
  
 0.975
ccmC
Probable heme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
  
 0.975
cutA2
Putative protein disulfide-isomerase; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.
  
 
 0.936
msrA
Putative peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
 0.922
ccmB
Probable heme exporter protein B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
  
 0.919
ccmA
Probable heme exporter protein A; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
   
 0.904
ahpC
Alkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
  
 0.851
Your Current Organism:
Azoarcus sp. BH72
NCBI taxonomy Id: 62928
Other names: A. sp. BH72
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