node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ROP_05840 | ROP_39790 | ROP_05840 | ROP_39790 | Putative proteasome accessory factor. | Hypothetical protein. | 0.726 |
ROP_05840 | arc | ROP_05840 | ROP_05870 | Putative proteasome accessory factor. | ATPase ARC; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.898 |
ROP_05840 | pafA | ROP_05840 | ROP_05790 | Putative proteasome accessory factor. | Proteasome accessory factor A; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.422 |
ROP_05840 | prcA | ROP_05840 | ROP_05810 | Putative proteasome accessory factor. | 20S proteasome alpha-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.958 |
ROP_05840 | prcB | ROP_05840 | ROP_05820 | Putative proteasome accessory factor. | 20S proteasome beta-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.955 |
ROP_05840 | pup | ROP_05840 | ROP_05830 | Putative proteasome accessory factor. | Putative proteasome accessory factor; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.941 |
ROP_11470 | ROP_18770 | ROP_11470 | ROP_18770 | Hypothetical protein. | Putative AAA family ATPase; Belongs to the AAA ATPase family. | 0.639 |
ROP_11470 | arc | ROP_11470 | ROP_05870 | Hypothetical protein. | ATPase ARC; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.991 |
ROP_11470 | glpk | ROP_11470 | ROP_63250 | Hypothetical protein. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.983 |
ROP_11470 | prcA | ROP_11470 | ROP_05810 | Hypothetical protein. | 20S proteasome alpha-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.938 |
ROP_11470 | prcB | ROP_11470 | ROP_05820 | Hypothetical protein. | 20S proteasome beta-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.938 |
ROP_18770 | ROP_11470 | ROP_18770 | ROP_11470 | Putative AAA family ATPase; Belongs to the AAA ATPase family. | Hypothetical protein. | 0.639 |
ROP_18770 | arc | ROP_18770 | ROP_05870 | Putative AAA family ATPase; Belongs to the AAA ATPase family. | ATPase ARC; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.695 |
ROP_18770 | glpk | ROP_18770 | ROP_63250 | Putative AAA family ATPase; Belongs to the AAA ATPase family. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. | 0.835 |
ROP_18770 | prcA | ROP_18770 | ROP_05810 | Putative AAA family ATPase; Belongs to the AAA ATPase family. | 20S proteasome alpha-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.695 |
ROP_18770 | prcB | ROP_18770 | ROP_05820 | Putative AAA family ATPase; Belongs to the AAA ATPase family. | 20S proteasome beta-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.730 |
ROP_39790 | ROP_05840 | ROP_39790 | ROP_05840 | Hypothetical protein. | Putative proteasome accessory factor. | 0.726 |
ROP_39790 | arc | ROP_39790 | ROP_05870 | Hypothetical protein. | ATPase ARC; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.843 |
ROP_39790 | pafA | ROP_39790 | ROP_05790 | Hypothetical protein. | Proteasome accessory factor A; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.761 |
ROP_39790 | prcA | ROP_39790 | ROP_05810 | Hypothetical protein. | 20S proteasome alpha-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.989 |