node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alr | ddl | ROP_62400 | ROP_65580 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine--D-alanine ligase; Cell wall formation. | 0.993 |
alr | murA | ROP_62400 | ROP_11780 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.744 |
alr | murB | ROP_62400 | ROP_17580 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.647 |
alr | murC | ROP_62400 | ROP_08150 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.791 |
alr | murD | ROP_62400 | ROP_08180 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.722 |
alr | murF | ROP_62400 | ROP_08200 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.935 |
alr | murG | ROP_62400 | ROP_08160 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.803 |
ddl | alr | ROP_65580 | ROP_62400 | D-alanine--D-alanine ligase; Cell wall formation. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.993 |
ddl | ftsQ | ROP_65580 | ROP_08140 | D-alanine--D-alanine ligase; Cell wall formation. | Putative cell division protein FtsQ; Essential cell division protein. | 0.913 |
ddl | gpsA-2 | ROP_65580 | ROP_65560 | D-alanine--D-alanine ligase; Cell wall formation. | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Protein synonym:dihydroxyacetone-phosphate reductase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.867 |
ddl | lysX | ROP_65580 | ROP_35510 | D-alanine--D-alanine ligase; Cell wall formation. | Putative lysyl-tRNA synthetase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-l [...] | 0.858 |
ddl | murA | ROP_65580 | ROP_11780 | D-alanine--D-alanine ligase; Cell wall formation. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.932 |
ddl | murB | ROP_65580 | ROP_17580 | D-alanine--D-alanine ligase; Cell wall formation. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.861 |
ddl | murC | ROP_65580 | ROP_08150 | D-alanine--D-alanine ligase; Cell wall formation. | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.988 |
ddl | murD | ROP_65580 | ROP_08180 | D-alanine--D-alanine ligase; Cell wall formation. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.895 |
ddl | murF | ROP_65580 | ROP_08200 | D-alanine--D-alanine ligase; Cell wall formation. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.997 |
ddl | murG | ROP_65580 | ROP_08160 | D-alanine--D-alanine ligase; Cell wall formation. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.962 |
ftsQ | ddl | ROP_08140 | ROP_65580 | Putative cell division protein FtsQ; Essential cell division protein. | D-alanine--D-alanine ligase; Cell wall formation. | 0.913 |
ftsQ | lysX | ROP_08140 | ROP_35510 | Putative cell division protein FtsQ; Essential cell division protein. | Putative lysyl-tRNA synthetase; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-l [...] | 0.752 |
ftsQ | murB | ROP_08140 | ROP_17580 | Putative cell division protein FtsQ; Essential cell division protein. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.721 |