STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
speHAdenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (120 aa)    
Predicted Functional Partners:
speE
Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
 
 
 0.996
mat
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
  
  
 0.930
Tagg_0881
DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525:IPR018117; KEGG: sun:SUN_2438 cytosine-specific methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; SPTR: Q9YDP3 DNA (Cytosine-5-)-methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
  0.900
Tagg_1292
DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: ngo:NGO1894 putative 5-methylcytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; SPTR: B8D660 Cytosine-specific DNA methylase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
  0.900
Tagg_0384
COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR003042; KEGG: nam:NAMH_1575 geranylgeranyl hydrogenase; SPTR: A3DPI3 Putative uncharacterized protein; PFAM: Lycopene cyclase protein.
       0.825
Tagg_0382
Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterProIPR005841:IPR005844:IPR005843:IPR005845:IPR 016066; KEGG: cha:CHAB381_1789 phosphoglucosamine mutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; SPTR: A3DPI5 Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha [...]
     
 0.541
Tagg_1172
Agmatinase; COGs: COG0010 Arginase/agmatinase/formimionoglutamate hydrolase arginase family; InterPro IPR006035:IPR005925; KEGG: pub:SAR11_1329 agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; SPTR: B8D3B1 Agmatinase; TIGRFAM: agmatinase; PFAM: Arginase family; TIGRFAM: agmatinase; Belongs to the arginase family.
     
 0.528
Tagg_0818
Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
     
 0.487
Tagg_0528
Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR001303; KEGG: smd:Smed_2157 class II aldolase/adducin family protein; PFAM: class II aldolase/adducin family protein; SPTR: B8D3F9 Class II aldolase/adducin family protein; PFAM: Class II Aldolase and Adducin N-terminal domain; TIGRFAM: L-ribulose-5-phosphate 4-epimerase.
     
 0.474
gap
Glyceraldehyde-3-phosphate dehydrogenase, type II; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR000173:IPR000846:IPR006436; KEGG: ajs:Ajs_2165 glyceraldehyde-3-phosphate dehydrogenase; PFAM: glyceraldehyde 3-phosphate dehydrogenase; dihydrodipicolinate reductase; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating); SPTR: B8D2W6 Glyceraldehyde 3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceral [...]
  
  
 0.451
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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