STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
taw3Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (239 aa)    
Predicted Functional Partners:
taw1
Wyosine base formation domain protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
  
  
 0.609
dtdA
Protein of unknown function DUF516; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
       0.602
Tagg_1376
InterPro IPR006984; PFAM: Protein of unknown function DUF652; SPTR: A3DMS3 SSU processome protein Utp24; PFAM: Fcf1.
   
    0.545
tmcA
Protein of unknown function DUF699 ATPase putative; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
  
  
 0.498
Tagg_0803
CRISPR-associated autoregulator, DevR family; COGs: COG1857 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR002764:IPR010154; PFAM: CRISPR-associated regulatory Csa2 family protein; SPTR: B8D4S2 CRISPR-associated autoregulator, DevR family; TIGRFAM: CRISPR-associated regulatory protein, Csa2 family; CRISPR-associated autoregulator DevR family; PFAM: CRISPR-associated negative autoregulator DevR/Csa2; TIGRFAM: CRISPR-associated autoregulator DevR family; CRISPR-associated regulatory protein, Csa2 family.
  
     0.446
Tagg_0190
COGs: COG1224 DNA helicase TIP49 TBP-interacting protein; InterPro IPR010339:IPR003959:IPR003593; KEGG: similar to RuvB-like 2 (p47 protein); K11338 RuvB-like protein 2; PFAM: TIP49 domain protein; AAA ATPase central domain protein; SMART: AAA ATPase; SPTR: B8D378 TATA binding protein (TBP)-interacting protein (TIP49-like); PFAM: TIP49 C-terminus.
  
     0.440
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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