STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rad17Cell cycle checkpoint protein RAD17. (481 aa)    
Predicted Functional Partners:
Rfc4
Replication factor C subunit 4.
   
 0.987
RFC2
Replication factor C subunit 2.
    
 0.987
RFC5
Replication factor C subunit 5.
   
 0.987
RFC3
Replication factor C subunit 3.
   
 0.987
Rad9a
Cell cycle checkpoint control protein RAD9A.
   
 0.979
Ncbp2
Cell cycle checkpoint protein RAD1.
   
 0.970
ATR
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
   
 0.927
T01_12681
Uncharacterized protein.
   
 0.897
Topbp1
DNA topoisomerase 2-binding protein 1.
   
 0.854
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.853
Your Current Organism:
Trichinella spiralis
NCBI taxonomy Id: 6334
Other names: T. spiralis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.