STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Smyd3Histone-lysine N-methyltransferase SMYD3. (501 aa)    
Predicted Functional Partners:
KDM6A
Lysine-specific demethylase 6A.
   
 0.665
tp53
Cellular tumor antigen p53.
   
 0.654
FIE
Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM.
   
 0.621
T01_10030
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.599
T01_2654
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.599
ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2.
    
 0.587
Rbbp5
Retinoblastoma-binding protein 5.
    
 0.587
H2B-VII
Histone H2B; Belongs to the histone H2B family.
    
 0.567
SETD1B
Histone-lysine N-methyltransferase SETD1B.
    
 0.503
dpy-30
Dosage compensation protein dpy-30.
   
 0.501
Your Current Organism:
Trichinella spiralis
NCBI taxonomy Id: 6334
Other names: T. spiralis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.