node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACC78960.1 | ACC81018.1 | Npun_F0163 | Npun_F2457 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | 0.963 |
ACC78960.1 | ACC81019.1 | Npun_F0163 | Npun_F2458 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein; KEGG: mka:MK1440 3-isopropylmalate dehydratase large subunit; Belongs to the aconitase/IPM isomerase family. | 0.866 |
ACC78960.1 | ACC81025.1 | Npun_F0163 | Npun_F2464 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | PFAM: pyruvate carboxyltransferase; KEGG: sso:SSO0977 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.843 |
ACC78960.1 | ACC82443.1 | Npun_F0163 | Npun_F4065 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: ana:alr3522 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.973 |
ACC78960.1 | ilvC | Npun_F0163 | Npun_F3618 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.866 |
ACC78960.1 | ilvD | Npun_F0163 | Npun_R3783 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: ava:Ava_B0062 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.912 |
ACC78960.1 | leuA | Npun_F0163 | Npun_F0926 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.980 |
ACC78960.1 | leuA-2 | Npun_F0163 | Npun_R4081 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.906 |
ACC78960.1 | leuB | Npun_F0163 | Npun_R2802 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.991 |
ACC78960.1 | leuC | Npun_F0163 | Npun_F0162 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
ACC81018.1 | ACC78960.1 | Npun_F2457 | Npun_F0163 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.963 |
ACC81018.1 | ACC81019.1 | Npun_F2457 | Npun_F2458 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein; KEGG: mka:MK1440 3-isopropylmalate dehydratase large subunit; Belongs to the aconitase/IPM isomerase family. | 0.999 |
ACC81018.1 | ACC81025.1 | Npun_F2457 | Npun_F2464 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | PFAM: pyruvate carboxyltransferase; KEGG: sso:SSO0977 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.972 |
ACC81018.1 | ACC82443.1 | Npun_F2457 | Npun_F4065 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: ana:alr3522 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.725 |
ACC81018.1 | ilvC | Npun_F2457 | Npun_F3618 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.880 |
ACC81018.1 | ilvD | Npun_F2457 | Npun_R3783 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: ava:Ava_B0062 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.915 |
ACC81018.1 | leuA | Npun_F2457 | Npun_F0926 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.946 |
ACC81018.1 | leuA-2 | Npun_F2457 | Npun_R4081 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.950 |
ACC81018.1 | leuC | Npun_F2457 | Npun_F0162 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: bha:BH3057 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.991 |
ACC81019.1 | ACC78960.1 | Npun_F2458 | Npun_F0163 | TIGRFAM: homoaconitate hydratase family protein; 3-isopropylmalate dehydratase; PFAM: aconitate hydratase domain protein; KEGG: mka:MK1440 3-isopropylmalate dehydratase large subunit; Belongs to the aconitase/IPM isomerase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.866 |