node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VNG_1998H | pdaD | VNG_1998H | VNG_1999H | Hypothetical protein; Vng1998h. | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | 0.718 |
VNG_1998H | prrIV1 | VNG_1998H | VNG_2000G | Hypothetical protein; Vng1998h. | ATP-dependent 26S proteinase regulatory subunit 4 homolog; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding [...] | 0.632 |
VNG_1998H | yjbG | VNG_1998H | VNG_2001G | Hypothetical protein; Vng1998h. | Oligopeptidase; YjbG. | 0.414 |
aldY2 | pdaD | VNG_0771G | VNG_1999H | Aldehyde dehydrogenase (retinol); AldY2. | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | 0.725 |
argH | leuS | VNG_2436G | VNG_2223G | Argininosuccinate lyase; ArgH. | leucine-tRNA synthetase; LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.467 |
argH | pdaD | VNG_2436G | VNG_1999H | Argininosuccinate lyase; ArgH. | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | 0.800 |
leuS | argH | VNG_2223G | VNG_2436G | leucine-tRNA synthetase; LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family. | Argininosuccinate lyase; ArgH. | 0.467 |
leuS | pdaD | VNG_2223G | VNG_1999H | leucine-tRNA synthetase; LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family. | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | 0.479 |
leuS | speB | VNG_2223G | VNG_1767G | leucine-tRNA synthetase; LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family. | Agmatinase; SpeB; Belongs to the arginase family. | 0.419 |
mvaA | pdaD | VNG_1875G | VNG_1999H | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; MvaA; Belongs to the HMG-CoA reductase family. | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | 0.828 |
mvaA | pyrF | VNG_1875G | VNG_1673G | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; MvaA; Belongs to the HMG-CoA reductase family. | Orotidine-5'-monophosphate (Ura3); PyrF; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.785 |
nhaC3 | pdaD | VNG_1985C | VNG_1999H | Conserved hypothetical protein; Vng1985c. | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | 0.720 |
pdaD | VNG_1998H | VNG_1999H | VNG_1998H | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | Hypothetical protein; Vng1998h. | 0.718 |
pdaD | aldY2 | VNG_1999H | VNG_0771G | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | Aldehyde dehydrogenase (retinol); AldY2. | 0.725 |
pdaD | argH | VNG_1999H | VNG_2436G | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | Argininosuccinate lyase; ArgH. | 0.800 |
pdaD | leuS | VNG_1999H | VNG_2223G | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | leucine-tRNA synthetase; LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.479 |
pdaD | mvaA | VNG_1999H | VNG_1875G | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; MvaA; Belongs to the HMG-CoA reductase family. | 0.828 |
pdaD | nhaC3 | VNG_1999H | VNG_1985C | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | Conserved hypothetical protein; Vng1985c. | 0.720 |
pdaD | prrIV1 | VNG_1999H | VNG_2000G | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | ATP-dependent 26S proteinase regulatory subunit 4 homolog; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding [...] | 0.759 |
pdaD | pyrF | VNG_1999H | VNG_1673G | Hypothetical protein; Vng1999h; Belongs to the PdaD family. | Orotidine-5'-monophosphate (Ura3); PyrF; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.747 |