STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Slip_0511Isocitrate dehydrogenase, NADP-dependent; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR004439:IPR019818:IPR001804; KEGG: afl:Aflv_0505 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: B7GGT7 Isocitrate dehydrogenase [NADP]; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (422 aa)    
Predicted Functional Partners:
Slip_1559
COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterProIPR014362:IPR006095:IPR006097:IPR006096:IPR 016040; KEGG: cth:Cthe_0374 glutamate dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; PRIAM: Glutamate dehydrogenase (NADP(+)); SPTR: C6P885 Glutamate dehydrogenase (NADP(+)); PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.961
Slip_0043
InterPro IPR017896:IPR017900:IPR001450; KEGG: nth:Nther_0025 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: B2A312 4Fe-4S ferredoxin iron-sulfur binding domain protein.
   
 
 0.945
Slip_0040
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR009014:IPR015941:IPR002880; KEGG: swo:Swol_0036 putative keto/oxoacid ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: Q0B0V9 Putative keto/oxoacid ferredoxin oxidoreductase, alpha subunit; PFAM: domain.
   
 
 0.913
Slip_1772
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880:IPR005476:IPR015941:IPR009014; KEGG: swo:Swol_1400 2-oxoisovalerate ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; SPTR: Q0AX47 2-oxoisovalerate ferredoxin oxidoreductase, alpha subunit; PFAM: domain; Transketolase, C-terminal domain.
   
 
 0.913
Slip_0041
Thiamine pyrophosphate protein domain protein TPP-binding protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: swo:Swol_0037 putative keto/oxoacid ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Q0B0V8 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
     
 0.908
Slip_1762
Thiamine pyrophosphate protein domain protein TPP-binding protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: adg:Adeg_1384 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: C9R857 Thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
     
 0.908
Slip_1771
Thiamine pyrophosphate protein domain protein TPP-binding protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: swo:Swol_1399 putative keto/oxoacid ferredoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Q0AX48 Putative keto/oxoacid ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
     
 0.908
Slip_0042
COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR002869:IPR019752; KEGG: chy:CHY_0045 putative keto/oxoacid ferredoxin oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: Q3AG17 Putative keto/oxoacid ferredoxin oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase.
     
 0.905
Slip_1763
COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR002869; KEGG: tpd:Teth39_0467 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: B0KD36 Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase.
     
 0.905
Slip_1770
COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR002869; KEGG: swo:Swol_1398 2-oxoglutarate oxidoreductase gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: Q0AX49 2-oxoglutarate oxidoreductase gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase.
     
 0.905
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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