STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (381 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 0.999
Slip_2098
NADH dehydrogenase (quinone); COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterProIPR012336:IPR012335:IPR017900:IPR001949:IPR 017896:IPR011538:IPR019554:IPR019575:IPR001450; KEGG: swo:Swol_1701 NADH dehydrogenase (quinone); PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; 4Fe-4S ferredoxin iron-sulfur binding domain protein; PRIAM: NADH dehydrogenase (quinone); SPTR: Q0AWA5 NADH dehydrogenase (Quinone); PFAM: NADH-ubiquinone oxidoreductase-F ir [...]
  
 
 0.999
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 
 0.997
Slip_1731
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR001023:IPR013126:IPR018181; KEGG: swo:Swol_1452 molecular chaperone DnaK; PFAM: Heat shock protein 70; SPTR: Q0AWZ5 Molecular chaperone DnaK; PFAM: Hsp70 protein.
 0.993
Slip_0302
Molecular chaperone-like protein; COGs: COG0443 Molecular chaperone; KEGG: swo:Swol_0386 molecular chaperone-like protein; SPTR: Q0AZY0 Molecular chaperone-like protein; PFAM: Hsp70 protein; Belongs to the heat shock protein 70 family.
 
 0.981
Slip_2030
KEGG: adg:Adeg_1368 hypothetical protein; SPTR: C9R841 Putative uncharacterized protein.
  
 0.964
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.960
Slip_2268
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR001270:IPR003593:IPR001943:IPR004176:IPR 003959:IPR013093:IPR019489:IPR018368; KEGG: swo:Swol_2367 ATPases with chaperone activity, ATP-binding subunit; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: Q0AUE8 ATPases with chaperone activity, ATP-binding subunit; PFAM: AAA domain (Cdc48 subfamily); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; UvrB/uvrC mo [...]
  
 
 0.960
Slip_0846
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; InterPro IPR001763:IPR016156:IPR004099:IPR013027; KEGG: afl:Aflv_0303 multidomain redox protein (NAD(FAD)-dependent oxidoreductase; rhodanese domain; SirA-like redox domain; peroxiredoxin domain); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Rhodanese domain protein; SMART: Rhodanese domain protein; SPTR: B7GG08 Multidomain redox protein (NAD(FAD)-dependent oxidoreductase; Rhodanese domain; S [...]
  
 
 0.953
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
  
  
 0.946
Your Current Organism:
Syntrophothermus lipocalidus
NCBI taxonomy Id: 643648
Other names: S. lipocalidus DSM 12680, Syntrophothermus lipocalidus DSM 12680, Syntrophothermus lipocalidus TGB-C1, Syntrophothermus lipocalidus str. DSM 12680, Syntrophothermus lipocalidus strain DSM 12680
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