STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADR20772.1COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR016059: IPR012310: IPR012309; KEGG: cpi:Cpin_6857 ATP dependent DNA ligase; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; SPTR: ATP dependent DNA ligase; PFAM: ATP dependent DNA ligase domain; DNA ligase N terminus; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA ligase I, ATP-dependent (dnl1). (533 aa)    
Predicted Functional Partners:
ADR21126.1
Metallo-beta-lactamase; COGs: COG1236 exonuclease of the beta-lactamase fold involved in RNA processing; KEGG: zpr:ZPR_0470 metallo-beta-lactamase; SPTR: Metallo-beta-lactamase.
 0.987
ADR20773.1
ATP dependent helicase, Lhr family; COGs: COG1201 Lhr-like helicase; InterProIPR014021: IPR001650: IPR014001: IPR017170: IPR 011545: IPR013701; KEGG: gfo:GFO_3528 DEAD box helicase family protein; PFAM: DEAD/H associated domain protein; DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: DEAD box helicase family protein; PFAM: Helicase conserved C-terminal domain; DEAD/H associated; DEAD/DEAH box helicase.
 
    0.951
ADR21415.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.939
ADR20775.1
Metallophosphoesterase; COGs: COG1407 ICC-like phosphoesterase; InterPro IPR004843; KEGG: chu:CHU_3526 ICC-like phosphoesterase; PFAM: metallophosphoesterase; SPTR: Putative uncharacterized protein; PFAM: Calcineurin-like phosphoesterase; TIGRFAM: putative phosphoesterase, SbcD/Mre11-related.
 
   
 0.931
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
    
 0.920
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.899
ADR20799.1
PHP domain protein; COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR002054: IPR003141: IPR004013; KEGG: phe:Phep_3075 PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; DNA polymerase X; SPTR: PHP domain protein; manually curated; PFAM: PHP domain.
  
 0.801
ADR21049.1
3'-5' exonuclease, PolB; InterPro IPR019288; KEGG: rbi:RB2501_05965 hypothetical protein; PFAM: 3'-5' exonuclease, PolB-like; SPTR: Putative uncharacterized protein; PFAM: Predicted 3'-5' exonuclease related to the exonuclease domain of PolB.
   
 0.700
ADR22360.1
COGs: COG0708 Exonuclease III; InterProIPR000097: IPR004808: IPR005135: IPR020847: IPR 020848; KEGG: coc:Coch_1451 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
  
 
 0.670
ADR20774.1
Protein of unknown function DUF2147; InterPro IPR019223; KEGG: cts:Ctha_2007 hypothetical protein; PFAM: Protein of unknown function DUF2147; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized protein conserved in bacteria (DUF2147).
       0.645
Your Current Organism:
Marivirga tractuosa
NCBI taxonomy Id: 643867
Other names: Flexibacter tractuosus DSM 4126, Flexibacter tractuosus IFO 15989, M. tractuosa DSM 4126, Marivirga tractuosa DSM 4126, Marivirga tractuosa IFO 15989, Marivirga tractuosa str. DSM 4126, Marivirga tractuosa strain DSM 4126
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