STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psmBProteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (224 aa)    
Predicted Functional Partners:
psmA
Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.999
pan
26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
  
 0.996
rpl40e
KEGG: mfe:Mefer_1082 hypothetical protein; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.945
ADC69471.1
KEGG: mja:MJ1156 cell division protein CDC48; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: AAA ATPase central domain protein; AAA ATPase VAT domain protein; cell division protein 48 CDC48 domain 2; Vps4 oligomerisation domain protein; SMART: AAA ATPase.
  
 0.913
mtrA
Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family.
      
 0.884
ADC69679.1
KEGG: mfe:Mefer_1167 translation initiation factor, aIF-2BII family; TIGRFAM: translation initiation factor, aIF-2BII family; eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: initiation factor 2B related; Belongs to the eIF-2B alpha/beta/delta subunits family.
  
 
 0.777
ADC69690.1
PFAM: protein of unknown function DUF75; KEGG: mja:MJ0106 hypothetical protein.
 
 
 
 0.776
ADC69386.1
KEGG: kcr:Kcr_0726 hypothetical protein.
       0.773
ADC69388.1
KH-domain/beta-lactamase-domain protein; KEGG: mja:MJ1236 putative mRNA 3'-end processing factor 2; TIGRFAM: KH-domain/beta-lactamase-domain protein; PFAM: RNA-metabolising metallo-beta-lactamase; SMART: KH domain protein.
     
 0.717
ADC70285.1
TIGRFAM: thermosome; PFAM: chaperonin Cpn60/TCP-1; KEGG: mja:MJ0999 thermosome (ths).
 
 
 0.612
Your Current Organism:
Methanocaldococcus sp. FS40622
NCBI taxonomy Id: 644281
Other names: M. sp. FS406-22, Methanocaldococcus sp. FS406-22
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