STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Sgly_1411Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160; KEGG: ssm:Spirs_4224 diguanylate cyclase; PFAM: Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (382 aa)    
Predicted Functional Partners:
Sgly_2699
Metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterPro IPR003607: IPR006674; KEGG: thx:Thet_1770 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Metal dependent phosphohydrolase; PFAM: HD domain; TIGRFAM: uncharacterized domain HDIG.
 
   0.965
Sgly_0138
Diguanylate phosphodiesterase; COGs: COG2200 FOG: EAL domain; InterPro IPR001633; KEGG: cac:CA_C2702 signal transduction protein; PFAM: Diguanylate phosphodiesterase, predicted; SMART: Diguanylate phosphodiesterase, predicted; SPTR: Possible signal transduction protein (Containing EAL, CBS and GGDEF domains); PFAM: EAL domain.
    0.964
Sgly_2231
COGs: COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase); InterPro IPR001789: IPR003661: IPR003594; KEGG: cth:Cthe_1826 response regulator receiver sensor signal transduction histidine kinase; PFAM: Signal transduction response regulator, receiver domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; ATPase-like, ATP-binding domain; SMART: Signal transduction response regulator, receiver domain; ATPase-like, ATP-binding domain; SPTR: Response regulator receiver sensor signal transduction histidine kinase; PFAM: Hi [...]
 
  
 0.916
Sgly_1644
Two component transcriptional regulator, winged helix family; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789: IPR001867; KEGG: dhd:Dhaf_1005 two component transcriptional regulator, winged helix family; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; SPTR: Putative uncharacterized protein; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal.
 
 
    0.900
Sgly_1383
NMT1/THI5-like protein; COGs: COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems periplasmic components; KEGG: cbe:Cbei_1941 NMT1/THI5-like protein; SPTR: NMT1/THI5-like protein; PFAM: NMT1/THI5 like.
 
      0.889
Sgly_2709
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR000014: IPR001610: IPR000160: IPR001633: IPR 013767; KEGG: tjr:TherJR_0997 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAS fold; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; PAC motif; PAS; SPTR: Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S); TIGRFAM: Diguanylate cyclase [...]
 
 0.858
Sgly_0137
Diguanylate cyclase/phosphodiesterase; COGs: COG2200 FOG: EAL domain; InterPro IPR001633: IPR000160; KEGG: cbe:Cbei_3303 diguanylate cyclase/phosphodiesterase; PFAM: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; SMART: Diguanylate phosphodiesterase, predicted; Diguanylate cyclase, predicted; SPTR: Diguanylate cyclase/phosphodiesterase; PFAM: EAL domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
 
    0.774
Sgly_3183
Metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterPro IPR006674: IPR003607: IPR006675; KEGG: dhd:Dhaf_0175 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Putative uncharacterized protein; TIGRFAM: HDIG; PFAM: HD domain; TIGRFAM: uncharacterized domain HDIG.
 
   0.773
Sgly_3188
Metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterPro IPR006674: IPR003607; KEGG: cac:CA_C3650 HD-GYP domain-containing protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: HD domain protein; PFAM: HD domain; TIGRFAM: uncharacterized domain HDIG.
 
   0.773
Sgly_3163
COGs: COG2206 HD-GYP domain; InterPro IPR001789: IPR006674: IPR003607; KEGG: cth:Cthe_0725 response regulator receiver modulated metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; Metal-dependent phosphohydrolase, HD domain; SPTR: Response regulator receiver modulated metal dependent phosphohydrolase; PFAM: Domain of unknown function (DUF3369); HD domain; Response regulator receiver domain; TIGRFAM: uncharacterized domain HDIG.
 
  
 0.764
Your Current Organism:
Syntrophobotulus glycolicus
NCBI taxonomy Id: 645991
Other names: S. glycolicus DSM 8271, Syntrophobotulus glycolicus DSM 8271, Syntrophobotulus glycolicus str. DSM 8271, Syntrophobotulus glycolicus strain DSM 8271
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.