STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Lbys_1257Succinate CoA transferase; COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702:IPR017821; KEGG: bba:Bd1620 acetyl-CoA hydrolase/transferase family protein; PFAM: acetyl-CoA hydrolase/transferase; PRIAM: Acetyl-CoA hydrolase; SPTR: Acetyl-CoA hydrolase/transferase family protein; TIGRFAM: succinate CoA transferase; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases. (497 aa)    
Predicted Functional Partners:
Lbys_3134
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 0.934
Lbys_1690
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 
 
  0.921
Lbys_3592
COGs: COG0183 Acetyl-CoA acetyltransferase; InterProIPR020610:IPR020613:IPR020616:IPR020617:IPR 002155; KEGG: dfe:Dfer_2430 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; PRIAM: Acetyl-CoA C-acetyltransferase; SPTR: Acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.918
Lbys_1333
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078:IPR003016; KEGG: chu:CHU_1755 dihydrolipoyllysine-residue acetyltransferase (dihydrolipoamide S-acetyltransferase); PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate [...]
   
 0.913
Lbys_3077
Catalytic domain-containing protein of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR001078; KEGG: mxa:MXAN_3454 2-oxo acid dehydrogenase acyltransferase catalytic subunit; PFAM: catalytic domain-containing protein of components of various dehydrogenase complexes; SPTR: 2-oxo acid dehydrogenase acyltransferase catalytic domain protein; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain).
   
 0.913
Lbys_0218
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160:IPR015590:IPR011408; KEGG: fba:FIC_01836 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family.
  
 
 0.907
Lbys_0249
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590; KEGG: dfe:Dfer_5034 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Aldehyde Dehydrogenase; PFAM: Aldehyde dehydrogenase family.
  
 
 0.907
Lbys_1689
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
    
 0.907
Lbys_2891
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590:IPR016160:IPR012394; KEGG: lic:LIC12761 aldehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: Putative uncharacterized protein; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family.
  
 
 0.907
Lbys_2027
2-isopropylmalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR002034:IPR000891; KEGG: sli:Slin_5897 pyruvate carboxyltransferase; PFAM: pyruvate carboxyltransferase; SPTR: Pyruvate carboxyltransferase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family.
    
 0.905
Your Current Organism:
Leadbetterella byssophila
NCBI taxonomy Id: 649349
Other names: L. byssophila DSM 17132, Leadbetterella byssophila 4M15, Leadbetterella byssophila DSM 17132, Leadbetterella byssophila str. DSM 17132, Leadbetterella byssophila strain DSM 17132
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